慢性中枢神经系统疾病研究——缓慢、潜伏和温带病毒感染-猫眼课题宝

慢性中枢神经系统疾病研究——缓慢、潜伏和温带病毒感染

批准号：

3922452

负责人：

D CARLETON GAJDUSEK

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3922452

关键词：

Alzheimer's disease Huntington's disease Parkinson's disease autoimmune disorder brain neoplasms central nervous system disorders chronic disease /disorder communicable disease transmission congenital neuromuscular disorder degenerative motor system disease dementia electrofocusing encephalitis genetic disorder human morbidity human population genetics human subject iatrogenic disease immunofluorescence technique in situ hybridization international cooperation latent virus infection multiple sclerosis muscular dystrophy myelinopathy nervous system disorder diagnosis nervous system disorder epidemiology nervous system infection neuromuscular disorder diagnosis neurotropic virus nucleic acid hybridization partial seizure progressive multifocal leukoencephalopathy scrapie serology /serodiagnosis spongiform encephalopathy subacute sclerosing panencephalitis virus antigen virus classification virus cytopathogenic effect virus infection mechanism virus replication zoonosis

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中文摘要

翻译

研究阐明慢性退行性变的病因和发病机制以多发性硬化症、肌萎缩侧索硬化症、帕金森病-痴呆、帕金森氏症，皮克氏症和阿尔茨海默氏症，亨廷顿舞蹈症，核上性瘫痪、其他老年前期痴呆、脊髓小脑共济失调，癫痫，慢性脑炎伴局灶性癫痫，肌肉营养不良，慢性精神分裂症，自闭症，SSPE，PML，透析性脑病和颅内肿瘤。即使是家庭成员，显然，遗传性疾病可能是缓慢的病毒感染。亚急性海绵状病毒脑病：库鲁病和克氏病人的雅各布病(CJD)；瘙痒病和水貂脑病是由具有独特特性的非常规病毒引起微生物学和分子生物学的重要理论问题生物学；一个主要目标是阐明它们的结构和复制机制。可传播的病毒痴呆有世界范围内日益公认的死因：高发病率通过角膜移植或脑部手术传播，以及因接触患病或感染性脑部而产生的职业危害。为了确定病毒的常见感染模式，传染性病毒性痴呆的全球流行病学研究 (CJD)病例正在进行中，特别关注家庭聚集性的案件，并寻求可能的关系，瘙痒病绵羊给人类带来疾病。家族性和非家族性痴呆和老年性痴呆学习。脑组织特异性抗原的自身免疫反应中枢神经系统疾病正在深入调查中。DNA原位蛋白质的杂交和电泳法聚焦分配以及酶和杂交瘤免疫荧光以及许多其他技术-用于尝试识别病毒亚基和慢性病组织中的部分基因组。

英文摘要

Studies elucidate cause and pathogenesis of chronic degenerative CNS disorders with emphasis on MS, ALS, Parkinsonism-dementia, Parkinson's, Pick's and Alzheimer's disease, Huntington's chorea, supranuclear palsy, other presenile dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis with focal epilepsy, muscular dystrophies, chronic schizophrenia, autism, SSPE, PML, dialysis encephalopathy, and intracranial neoplasm. Even familial, apparently hereditary diseases may be slow virus infections. Subacute spongiform virus encephalopathies: kuru and Creutzfeldt- Jakob disease (CJD) of man; scrapie and mink encephalopathy are caused by unconventional viruses with unique properties posing important theoretical problems to microbiology and molecular biology; a major goal is elucidation of their structure and mechanisms of replication. Transmissible virus dementias are increasingly recognized worldwide causes of death: high incidence foci, transmission by corneal transplant or brain surgery, and occupational hazards from exposure to diseased or infectious brain. In order to determine the usual mode of infection with the virus, a worldwide epidemiological study of transmissible virus dementia (CJD) cases is underway with special attention to familial clusters of cases and with a quest for possible relationship of scrapie of sheep to the human disease. Familial and nonfamilial dementia and the dementias of senility are studied. The autoimmune responses to specific brain antigens in CNS diseases are under intensive investigation. DNA in situ hybridization and electrophoretic focusing partition of proteins along with enzymatic and hybridoma immunofluorescence and many other techniques are- used to try to identify viral subunits and partial genomes in tissues in chronic diseases.

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