TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

强迫症(OCD)现在被认为是一种 常见的精神障碍，大约在300万人中发生 仅在这个国家的人。在青少年中，流行率 也许高达1%。 我们分支机构的随访研究显示，这是一种慢性疾病 抑郁症和焦虑症的严重程度越来越高 时间到了。氯丙咪嗪对人体有高度特异性的有益作用 强迫症而去甲基米帕明(DMI)另一个三环 抗抑郁药与安慰剂没有什么不同。 关于脑成像的新研究(PET和CT扫描)，以及 Sydenham舞蹈病患者的调查，牵连 当脊髓液研究显示基底节异常时 脑脊液中低浓度的5-HIAA，主要是5-羟色胺 代谢产物，与更严重的强迫症有关。

Obsessive Compulsive Disorder (OCD) is now recognized as a common mental disorder, occurring in perhaps three million people in this country alone. In adolescents, the prevalence maybe as high as one percent. Follow-up studies in our Branch show a chronic course for the disorder with increasing severity of depression and anxiety over time. Clomipramine has a highly specific beneficial effect on obsessions while Desmethylimipramine (DMI) another tricyclic antidepressant did not differ from placebo. New studies with brain imaging (PET and CT scan), as well as a survey of patients with Sydenham's chorea, implicate abnormalities in the basal ganglia while spinal fluid studies show that low concentration of CSF 5-HIAA, the major serotonin metabolite, is associated with more severe OCD.