TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

氯丙咪嗪维持治疗的双盲停药研究 在20名强迫症青少年中发现，90%的人复发了 去甲基米帕明替代，不考虑先前药物的长度 治疗。这表明可能存在无限期的药物维持。 用现有的治疗方法治疗强迫症(OCD)。 地塞帕明与氯丙咪嗪治疗重度指甲15例双盲对照 没有其他精神障碍的咬合者发现氯丙咪嗪显著 在减少咬指甲行为方面表现出众。这扩大了强迫症的范围 另一种“过度打扮”行为的概念(与 毛发狂症和犬类肢端舔)。 10例女性脱毛症患者静息状态18FDG PET扫描研究 20名匹配的正常对照组发现脑整体血糖显著升高 双侧小脑毛滴虫组的代谢率 左顶叶区域归一化差异。一级亲属 强迫症患者的强迫症发生率显著高于配对的 对照组进一步支持拔毛症之间的关系 还有强迫症。 氟西汀对10只犬肢端舔的疗效优于芬氟拉明。 间接地将这种自然发生的犬类美容障碍与 发病机制与强迫症相似。

A double-blind discontinuation study of clomipramine maintenance treatment in 20 obsessive compulsive adolescents found that 90% relapsed with desmethylimipramine substitution regardless of length of prior drug treatment. This suggests that indefinite drug maintenance may be indicated in Obsessive Compulsive Disorder (OCD) with existing therapies. A double-blind comparison of desipramine and clomipramine in 15 severe nail biters without other psychiatric disorder found clomipramine significantly superior in reducing nailbiting behavior. This extends the OCD spectrum concept to another "excess grooming" behavior (in company with trichotillomania and canine acral lick). A resting state 18FDG PET scan study of 10 women with trichotillomania and 20 matched normal controls found significantly higher brain global glucose metabolic rate for the trichotillomanic group, with bilateral cerebellar and left parietal regional normalized differences. First degree relatives of trichotillomanics had a significantly higher rate of OCD than a matched control group further supporting the relationship between trichotillomania and OCD. Fluoxetine was superior to fenfluramine in 10 dogs with canine acral lick., indirectly linking this naturally occurring canine grooming disorder to a mechanism similar to that seen in OCD.