NEUROBIOLOGY OF ATTENTION DEFICIT DISORDER

定位可能的脑葡萄糖异常模式 注意力障碍成人的代谢和脑血流量 缺陷障碍（ADD）残留型，诊断的父母 多动儿童正在使用2- 正电子发射断层扫描脱氧氟葡萄糖法 （PET）。 到目前为止，已经有30次PET扫描在没有药物的情况下进行 在治疗期间进行了16次扫描 安非他命 为了了解的作用机制 治疗注意力缺陷的兴奋剂药物 多动障碍（ADDH），匹莫林的比较 （Cylert）、哌醋甲酯和苯丙胺开始治疗 研究这些药物的急性和慢性影响， 同样的受试者在外周测量多巴胺， 去甲肾上腺素催乳素和生长激素 行为维度之间的关系 冲动性、攻击性和单胺浓度 代谢产物，特别是5-HIAA，在儿童的脊髓液 行为障碍和/或注意力缺陷障碍， 考察 CSF 5-HIAA降低与 注意力集中和冲动的攻击行为 在冲动的成年人中报告。 血清素外周指标 和儿茶酚胺是随着个性沿着获得的， 冲动性和攻击性 17名受试者 至今被研究。 初步比较了10个 行为障碍与10例年龄匹配的强迫症 儿童，显示CSF 5-HIAA较低的趋势（p = 0.09） 注意力集中的行为障碍 在品行障碍中 示例中，较低的值与破坏性较大的 行为

To localize possible abnormal patterns of cerebral glucose metabolism and cerebral blood flow in adults with Attention Deficit Disorder (ADD) Residual Type, parents of diagnosed hyperactive children are being studied using the 2- deoxyfluoroglucose method of Positron Emission Tomography (PET). To date, 30 PET scans have been performed without medication and 16 scans have been done during treatment with dextroamphetamine. To understand the mechanism of action of stimulant medication in the treatment of Attention Deficit Disorder with Hyperactivity (ADDH), a comparison of pemoline (Cylert), methylphenidate, and dextroamphetamine was initiated to examine the acute and chronic effects of these medications in the same subjects on peripheral measures of dopamine, norepinephrine, prolactin, and growth hormone. The relationships between the behavioral dimensions of impulsivity, aggression, and concentrations of monoamine metabolites, particularly 5-HIAA, in the spinal fluid of children with conduct disorder and/or attention deficit disorder, is being examined. Associations between decreased CSF 5-HIAA concentrations and impulsive aggressive behavior have been reported in impulsive adults. Peripheral measures of serotonin and catecholamines are being obtained along with personality, impulsivity and aggression measures. Seventeen subjects have been studied to date. A preliminary comparison between ten Conduct Disorder and ten age-matched Obsessive Compulsive children, shows a trend (p =.09) for lower CSF 5-HIAA concentration in conduct disorder. Within the conduct disorder sample, lower values are associated with more destructive behavior.