NEUROBIOLOGY OF DISRUPTIVE BEHAVIOR DISORDERS

对29名（100%）儿童和青少年进行了为期两年的前瞻性随访， 破坏性行为障碍发现基线腰椎CSF单胺 代谢物浓度和自主神经系统反应性 显著的预测值（Kruesi et al，1992）。 5-HIAA浓度 显著预测随访期间身体攻击的严重程度。 皮肤电导水平显着预测机构化。 CSF HVA预测了自杀企图。 方向与预测一致， CSF 5-HIAA和较低的自主活动与不良结局相关。 此外，当分层进入多元回归， 判别函数分析后，各种其他非实验室 预测因子，CSF和自主神经测量仍然显著有助于 方差 慢性阻塞性肺疾病患者兴奋性药物反应的初步研究 多动症和图雷特氏症表明，不仅一些 患者的抽搐不会因兴奋剂而恶化，但随着时间的推移和/或增加 在剂量，抽搐甚至可以改善。

A two-year prospective follow-up of 29 (100%) children and adolescents with disruptive behavior disorders found that baseline lumbar CSF monoamine metabolite concentration and autonomic nervous system reactivity had significant predictive value (Kruesi et al, 1992). 5-HIAA concentration significantly predicted severity of physical aggression during follow-up. Skin conductance level significantly predicted institutionalization. CSF HVA predicted suicide attempts. The direction was as predicted, with lower CSF 5-HIAA and lower autonomic activity correlated with poor outcome. Moreover, when hierarchically entered into multiple regression and discriminant function analyses after a variety of other non-laboratory predictors, CSF and autonomic measures still contributed significantly to the variance. Preliminary studies of stimulant drug response of patients with Hyperactivity and Tourette's disorder indicates that not only do some patients' tics not worsen on stimulants, but that over time and/or increase in dose, tics may even improve.