THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

试图找到一种更好的方法来治疗类固醇抵抗性肌炎 （除了包涵体肌炎），我们进行了随机 静脉注射甲氨蝶呤与甲酰四氢叶酸的交叉试验 甲氨蝶呤和硫唑嘌呤的组合。 患者的累积是 完成了三分之二。 我们对该疗法进行了两次广泛的回顾性分析 肌炎 其中一个，在100多名病人中， 响应可用，分析了影响 对泼尼松、甲氨蝶呤和硫唑嘌呤的反应。 另一个是 一个密切的分析反应类固醇和细胞毒性治疗， 近30例包涵体肌炎患者，包括一项分析 第一次在这种情况下进行对照治疗试验， 我们在过去几年里进行的。 这些现在已经被 公开.

In an attempt to find a better way to treat steroid-resistant myositis (other than inclusion body myositis), we have carried out a randomized crossover trial of intravenous methotrexate with leukovorin rescue and a combination of methotrexate and azathioprine. Accrual of patients is about two-thirds complete. We have carried out two extensive retrospective analyses of the therapy of myositis. One, of well over 100 patients on whom thorough records of responses were available, was analyzed for the factors that influence the responses to prednisione, methotrexate, and azathioprine. The other was a close analysis of the responses to steroid and cytotoxic therapy in almost 30 patients with inclusion body myositis, including an analysis of the first ever controlled therapeutic trial in that condition which we carried out over the past several years. These have now been published.