Cerebral amyloid angiopathy and intracerebral haemorrhage: community-based cohort study, biobank, and record linkage

脑淀粉样血管病和脑出血：基于社区的队列研究、生物库和记录关联

• 批准号: G1002605/1
• 负责人: Rustam Salman
• 金额: $ 214.61万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002605%2F1
• 关键词: Cerebral; amyloid; angiopathy; intracerebral; haemorrhage

This research is about cerebral amyloid angiopathy, which is known as ‘CAA‘ for short. In CAA, a protein gradually damages blood vessels in the brain. CAA can be found in elderly people who are healthy, who have dementia, or who have stroke due to brain haemorrhage.This research aims to find out how CAA causes brain haemorrhages, how to recognise CAA in people with brain haemorrhage before they die, and what predicts whether someone who survives brain haemorrhage might have another one.The research will: (1) recruit adults with brain haemorrhage in one community, (2) obtain consent to collect information about them, their brain scans and their brain tissue, (3) compare them to people without brain haemorrhage in another MRC study, (4) compare different types of brain haemorrhage to eachother, and (5) study the outcome after different types of brain haemorrhage in one country.This research might benefit patients by finding out why brain haemorrhage happens, how to recognise its cause, and who is most likely to have it again. This could help identify ways of preventing brain haemorrhage in future, which will become more common as the population ages. Studying ageing is one of the MRC‘s two research priorities.

本研究是关于脑淀粉样血管病（简称CAA）的研究。在CAA中，一种蛋白质会逐渐损害大脑中的血管。CAA可以在健康的老年人中发现，患有痴呆症或因脑出血而中风的人。这项研究旨在了解CAA如何导致脑出血，如何在脑出血患者死亡前识别CAA，以及如何预测脑出血幸存者是否会再次发生CAA。该研究将：（1）在一个社区招募患有脑出血的成年人，（2）获得同意收集关于他们的信息，他们的脑部扫描和脑组织，（3）将他们与另一项MRC研究中没有脑出血的人进行比较，（4）将不同类型的脑出血相互比较，（5）研究一个国家不同类型的脑出血后的结果。这项研究可能会通过发现脑出血发生的原因、如何识别其原因以及谁最有可能再次患上脑出血而使患者受益。这可能有助于确定未来预防脑出血的方法，随着人口老龄化，脑出血将变得更加普遍。研究老龄化是MRC的两个研究重点之一。