PHARMACOKINETICS OF A NEW ANTI-FUNGAL AGENT

新型抗真菌剂的药代动力学

• 批准号: 4691986
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4691986
• 关键词: analytical method; antifungal agents; blood chemistry; drug metabolism; high performance liquid chromatography; microorganism disease chemotherapy; pharmacokinetics

Formal study has yet to be designed. We have been attempting to develop a new quantitation procedure for SF-86327 in plasma that is much simpler than an extremely time consuming method obtained from Sandoz, AG. We have successfully developed a quick method for quantitation of SF-86327 from plasma which has about 1/3 to 1/4th the sensitivity of the earlier procedure but requires at least 1/20th of the time for drug extraction. We are evaluating and seeking appropriate internal standards for possible incorporation in our method. Method employs a high performance liquid chromatographic system with fluorescence detection.

正式的研究尚未设计完成。我们一直在尝试开发一种 血浆中SF-86327的新定量方法比 从Sandoz，AG获得的一种非常耗时的方法。我们有 成功地建立了SF-86327的快速定量方法 灵敏度约为早期的1/3至1/4的等离子体 程序，但需要至少1/20的时间进行药物提取。我们 正在评估和寻找适当的内部标准，以 结合到我们的方法中。方法使用一种高性能液体 具有荧光检测的层析系统。