KINETICS OF THIOPENTAL DURING CARDIOPULMONARY BYPASS AND CORONARY REPERFUSION

心肺转流术和冠状动脉再灌注期间硫喷妥钠的动力学

• 批准号: 4691984
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4691984
• 关键词: anesthetics; blood chemistry; dosage; drug metabolism; heart /lung bypass; heart revascularization; high performance liquid chromatography; human subject; pharmacokinetics; thiopental

The use of sodium thiopental, an ultrashort acting barbiturate, in cardiac surgical patients after aortic cross clamp is quite common. We have evaluated 16 patients by designing a study to quantitate drug levels in plasma during the hypothermic state in cardiopulmonary bypass procedure, in order to define effects of hyperthermia and non-pulsatile perfusion on thiopental kinetics. We have determined the actual levels of the anesthetic at the reinstitution of coronary perfusion. We have employed a simple high performance liquid chromatographic procedure for quantitation of thiopental from plasma collected from these patients. Apart from significant variability in thiopental levels, it appears that a redistribution of the drug occurs at the time of reperfusion which may determine the efficacy of the anesthetic dose. We are proceeding with analysis of data which suggests that we need to study another 5-10 patients.

硫喷妥钠是一种超短效巴比妥酸盐