DISPOSITION OF FENTANYL IN CARDIOPULMONARY BYPASS--EFFECTS OF HYPOTHERMIA

芬太尼在体外循环中的处置——低温的影响

• 批准号: 4691991
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4691991
• 关键词: anesthetics; blood chemistry; drug metabolism; fentanyl; gas chromatography; heart /lung bypass; heart revascularization; human subject; pharmacokinetics

Fentanyl, a new synthetic opiate with a potency that is 50 times that of morphine, is presently being investigated in cardiopulmonary bypass patients for its anesthetic properties. We have designed an initial clinical study to evaluate the influence of hypothermia and non-pulsatile perfusion on fentanyl disposition. Attempts will be made to correlate fentanyl levels at reinstitution of coronary perfusion with clinical responses. Following the drug administration, serial blood samples were collected throughout the cardiopulmonary bypass procedure. Quantitation of fentanyl will be done using a gas chromatographic method that employs N-P detector. We have clinically tested 7 patients by now and are proceeding with analyis.

芬太尼，一种新的合成阿片类药物，其效力是 吗啡，目前正在研究在心肺分流术 患者的麻醉特性。 我们设计了一个 临床研究，以评估低温和非脉动的影响， 灌注对芬太尼处置的影响。 我们将尝试把 冠状动脉灌注重建时芬太尼水平与临床 应答 给药后，连续采集血样， 在整个心肺转流手术过程中收集。 定量 芬太尼将使用气相色谱法，采用N-P 检测器 我们已经对7名患者进行了临床测试， 分析。