INTRACAROTID HIGH-DOSE CISPLATIN FOR BRAIN TUMOR--ESTIMATING ICG CLEARANCE

颈动脉内高剂量顺铂治疗脑肿瘤——估计 ICG 清除率

• 批准号: 3939451
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939451
• 关键词: antineoplastics; brain neoplasms; central nervous system neoplasms; cis platinum compound; dosage; drug administration routes; drug adverse effect; drug metabolism; human subject; indocyanine green; neoplasm /cancer chemotherapy; pharmacokinetics; spectrometry

In order to be able to optimally dose patients with cisplatin and minimize its systemic toxicity, we have evaluated a total of 4 patients who were administered 5 mg bolus of indocyamine green (ICG) along with 0.5 mg/ml ICG infusion at 3.5 mg/min into the internal carotid artery. Plasma ICG levels were quickly measured by using a spectrophotometric method in the first three and a relatively simple MPLC method (abs: 800 nm) in the last patient. ICG clearance as a function of jugular aspiration flow rate (range: 50-350 mg/min). Results in patient appear to show a linear correlation (r greater than 0.95) and support preclinical investigation in monkeys that correlated the flow rates with ICG clearance.

为了能够最佳地给患者施用顺铂， 最大限度地减少其全身毒性，我们总共评估了4种 接受5 mg吲哚菁绿色推注的患者 (ICG)沿着0.5 mg/ml ICG以3.5 mg/min输注至 颈内动脉 快速测量血浆ICG水平 用分光光度法测定了前三种方法的含量， 最后一名患者采用相对简单的MPLC方法（abs：800 nm）。 ICG清除率作为颈静脉抽吸流速的函数 （范围：50-350 mg/min）。 患者的结果似乎显示 线性相关性（r大于0.95），并支持临床前 在猴中进行的将流速与ICG相关联的研究 间隙