DISPOSITION OF FENTANYL IN CARDIOPULMONARY BYPASS--EFFECTS OF HYPOTHERMIA

芬太尼在体外循环中的处置——低温的影响

• 批准号: 3939448
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939448
• 关键词: anesthetics; blood chemistry; drug metabolism; fentanyl; gas chromatography; heart /lung bypass; heart revascularization; human subject; hypothermia; pharmacokinetics

We have investigated the pharmacokinetics of fentanyl bypass. We are attempting to evaluate the effect of hemodilution and hypothermia on an extensively metabolized compound, e.g., fentanyl. We have, until now, finished the analysis of plasma samples (approx: 200) obtained from this study using a sensitive (1 ng/ml) and specific gas chromatographic procedure that employs N-P detector. We are planning to proceed with the kinetic analysis of the data.

我们研究了芬太尼转流的药代动力学。 我们正在尝试评估血液稀释和 对广泛代谢的化合物进行低温治疗，例如， 芬太尼。到目前为止，我们已经完成了对血浆的分析 从这项研究中获得的样本(约：200)使用敏感的 (1 ng/ml)和特定的气相色谱程序 采用N-P检测器。我们正计划继续进行 对数据进行动力学分析。