COGNITIVE, ENDOCRINE EFFECTS & KINETICS OF NICOTINE IN CONTROLS & NEUROPSYCH PTS

认知、内分泌影响

• 批准号: 4691988
• 负责人: P K NARANG
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4691988
• 关键词: blood chemistry; cognition; dosage; drug administration routes; drug adverse effect; drug metabolism; drug tolerance; endocrine pharmacology; high performance liquid chromatography; human subject; learning stimulant; memory; nervous system disorder; neuroendocrine system; nicotine; pharmacokinetics; ultraviolet radiation

Studies in animals have shown that nicotine facilitates task acquisition and memory consolidation. The purpose of this pilot study is to assess dose, side effects, tolerance and nicotine disposition in normal healthy males and females following I.V. administration of 0.7 to 2.0 mcg/Kg/minute nicotine base. Our laboratory has developed a quick procedure for the quantitation of nicotine from plasma using high peformance liquid chromatography (sensitivity - 1 ng/ml) with UV detection. We have performed analysis on the first 9 controls to obtain initial estimates on the toxicity of the drug. Correlation analysis with neuroendocrine and cognitive effects will be undertaken in the near future.

在动物身上的研究表明，尼古丁促进任务获得 和记忆巩固。这项初步研究的目的是评估 正常健康人的剂量、副作用、耐受性和尼古丁倾向 静脉注射0.7至2.0微克/公斤/分钟后的男性和女性 尼古丁基料。我们的实验室已经开发了一种快速程序来检测 高效液体法定量测定血浆中的尼古丁 紫外检测层析法(灵敏度-1 ng/ml)。我们已经表演了 对首批9项控制措施进行分析，以获得关于 药物的毒性。与神经内分泌、神经内分泌的相关性分析 认知效应将在不久的将来进行。