ENERGY EXPENDITURE AND BODY COMPOSITION IN PATIENTS WITH SPINAL CORD INJURIES

脊髓损伤患者的能量消耗和身体成分

• 批准号: 5202083
• 负责人: R PRATLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5202083
• 关键词: basal metabolism; bioenergetics; body composition; calorimetry; cardiovascular disorder; disease /disorder proneness /risk; human subject; noninsulin dependent diabetes mellitus; paraplegia; radiography; spinal cord injury

Lean body mass is an important determinant of resting and 24-hour energy expenditure. Individuals who suffer spinal cord injuries experience a marked loss of muscle mass which may decrease energy expenditure and promote an increase in body fat. This project tests the hypothesis that energy expenditure is decreased in patients with spinal cord injuries as a consequence of their marked muscle atrophy. Resting metabolic rate will be measured by indirect calorimetry and body composition by dual- energy X-ray absorptiometry (DXA) in subjects with spinal cord injuries and compared to results obtained in age-matched able-bodied individuals. In addition, 24-hour energy expenditure will be measured in a respiratory chamber in a subgroup of paraplegic individuals who are fully independent in self care. A better understanding of the relationship between changes in body composition and energy expenditure in patients with spinal cord injuries may eventually suggest strategies to reduce the excess risk of diabetes and cardiovascular disease in this population. These studies also may improve our understanding of the contributions of muscle mass to energy expenditure in the general population as well as in other special populations characterized by a loss of muscle mass (such as the elderly).

瘦体重是休息和24小时能量的重要决定因素 支出 脊髓损伤的患者会经历 肌肉质量明显减少，这可能会减少能量消耗， 促进身体脂肪的增加。 这个项目测试的假设， 脊髓损伤患者的能量消耗减少， 这是他们明显肌肉萎缩的结果 静息代谢率 将通过间接量热法和身体成分双- 脊髓损伤受试者的能量X射线吸收测定法（DXA） 并与年龄匹配的健全个体中获得的结果进行比较。 此外，24小时能量消耗将在呼吸系统中测量。 完全独立的截瘫个体的亚组中的腔室 在自我照顾。 更好地理解变化之间的关系 脊髓损伤患者身体成分和能量消耗 伤害可能最终建议策略，以减少过度的风险， 糖尿病和心血管疾病。 这些研究 也可以提高我们对肌肉质量的贡献的理解 一般人群以及其他人群的能量消耗 以肌肉质量损失为特征的特殊人群（如 老年人）。