ENERGY EXPENDITURE AND BODY COMPOSITION IN PATIENTS WITH SPINAL CORD INJURIES

脊髓损伤患者的能量消耗和身体成分

• 批准号: 2573712
• 负责人: R PRATLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2573712
• 关键词: adipose tissue; atrophy; basal metabolism; bioenergetics; body composition; calorimetry; cardiovascular disorder; clinical research; disease /disorder proneness /risk; human subject; muscle; noninsulin dependent diabetes mellitus; paraplegia; photon absorptiometry; spinal cord injury

Lean body mass is an important determinant of resting and 24-hour energy expenditure. Individuals who suffer spinal cord injuries experience a marked loss of muscle mass which may decrease energy expenditure and promote an increase in body fat. This project tests the hypothesis that energy expenditure is decreased in patients with spinal cord injuries as a consequence of their marked muscle atrophy. Resting metabolic rate (measured by indirect calorimetry) and body composition (dual-energy X-ray absorptiometry (DXA)) will be compared in subjects with spinal cord injuries and age-matched able-bodied individuals. In addition, 24-hour energy expenditure is measured in a respiratory chamber in paraplegic individuals who are fully independent in self care. To date, 17 individuals (12 males, 5 females) with spinal cord injuries have been studied. Of these, 9 were paraplegic and 8 quadraplegic (7 males and 1 female). Mean percent body fat was 10-12% higher than predicted, whereas lean body mass was 10-15% less than predicted. Percent body fat was significantly correlated with lesion level (p<0.05) and could be predicted using a linear combination of thigh, hip, and triceps skinfolds which together explained 90% of the variance in percent body fat. Resting metabolic rate also was 12-15% less than expected. These results confirm earlier observations that individuals who have suffered spinal cord injuries have less lean body mass and a greater proportion of fat than able-bodied controls. In addtion, energy expenditure is lower in proportion to the loss of lean body mass. A better understanding of the relationship between changes in body composition and energy expenditure in patients with spinal cord injuries may eventually suggest strategies to reduce the excess risk of diabetes and cardiovascular disease in this population. These studies also may improve our understanding of the contributions of muscle mass to energy expenditure in the general population as well as in other special populations characterized by a loss of muscle mass (such as the elderly).

去脂体重是休息和 24 小时的重要决定因素 能量消耗。 脊髓损伤的人 肌肉质量明显下降，这可能会降低能量 支出并促进体内脂肪的增加。 本项目测试 假设患者的能量消耗减少 由于明显的肌肉萎缩而导致脊髓损伤。 静息代谢率（通过间接热量法测量）和身体 将比较成分（双能 X 射线吸收测定法 (DXA)） 在患有脊髓损伤且年龄匹配的身体健全的受试者中 个人。 此外，24小时的能量消耗是以 完全瘫痪的截瘫患者的呼吸室 能独立照顾自己。迄今为止，已有 17 人（12 名男性、5 名 对患有脊髓损伤的女性）进行了研究。 其中，9 截瘫者 8 例，四肢瘫痪 8 例（男 7 例，女 1 例）。 意思是 体脂百分比比预期高 10-12%，而瘦体百分比 质量比预期少 10-15%。 身体脂肪百分比是 与病变程度显着相关（p<0.05），可 使用大腿、臀部和三头肌的线性组合进行预测 皮褶共同解释了 90% 的身体百分比差异 胖的。 静息代谢率也比预期低 12-15%。 这些结果证实了早期的观察结果，即具有以下特征的个体 遭受脊髓损伤的人的去脂体重较少，而体重较大 脂肪比例高于健全对照。 此外，能源 支出与去脂体重的损失成比例地降低。 一个 更好地理解身体变化之间的关系 脊髓患者的成分和能量消耗 伤害最终可能会提出减少过度风险的策略 该人群中糖尿病和心血管疾病的发病率。 这些 研究还可以提高我们对以下贡献的理解： 一般人群的肌肉质量与能量消耗以及 在其他以肌肉质量损失为特征的特殊人群中 （比如老人）。