ENERGY EXPENDITURE AND BODY COMPOSITION IN PATIENTS WITH SPINAL CORD INJURIES

脊髓损伤患者的能量消耗和身体成分

• 批准号: 6105960
• 负责人: R PRATLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6105960
• 关键词: adipose tissue; atrophy; basal metabolism; bioenergetics; body composition; calorimetry; cardiovascular disorder; clinical research; disease /disorder proneness /risk; human subject; muscle; noninsulin dependent diabetes mellitus; paraplegia; photon absorptiometry; spinal cord injury

Lean body mass is an important determinant of resting and 24-hour energy expenditure. Individuals who suffer spinal cord injuries (SCI) experience a marked loss of muscle mass which may decrease energy expenditure and promote an increase in body fat. This project was designed to test the hypothesis that energy expenditure is decreased in patients with spinal cord injuries as a consequence of their marked muscle atrophy . 24-hour energy expenditure (respiratory chamber), resting metabolic rate (measured by indirect calorimetry) and body composition (dual-energy X-ray absorptiometry (DXA)) were compared in subjects with spinal cord injuries and age-matched able-bodied individuals. 24-hour energy expenditure was lower in 10 males with SCI compared to 59 able-bodied controls (1870+/-73 vs. 2376+/-45 Kcal/24h, p<0.01). After adjusting for differences in fat-free mass, fat mass and age, the resting metabolic rate remained lower in SCI patients than controls (-162 kcal/day, p<0.01) indicating that factors besides the loss of fat-free mass, such as lower sympathetic nervous system activity or a shift to lower oxidative capacity type II muscle fiber may contribute to the lower energy expenditure in SCI patients. Strategies to reduce the excess risk of obesity, diabetes and cardiovascular disease in this population must, therefore, consider the multifactorial nature of the decrease in energy expenditure in this population. This project has been terminated as of the 1997 fiscal year.

去脂体重是一个重要的决定因素 休息和 24 小时能量消耗。受苦受难的个人 脊髓损伤 (SCI) 会导致肌肉质量明显损失 这可能会减少能量消耗并促进增加 身体脂肪。该项目旨在检验以下假设： 脊髓损伤患者的能量消耗减少 由于他们明显的肌肉萎缩。 24小时能量 消耗（呼吸室），静息代谢率（测量 通过间接量热法）和身体成分（双能 X 射线 比较脊髓受试者的吸收光度测定法（DXA） 伤害和年龄匹配的身体健全的人。 24小时能量 与 59 名患有 SCI 的男性相比，10 名男性的支出较低 健全对照（1870+/-73 vs. 2376+/-45 Kcal/24h，p<0.01）。 在调整去脂质量、脂肪质量和年龄的差异后， SCI 患者的静息代谢率仍然低于 对照（-162 kcal/天，p<0.01）表明除了 无脂肪质量损失，例如下交感神经系统 活性或转向较低氧化能力的 II 型肌纤维 可能有助于降低 SCI 患者的能量消耗。 降低肥胖、糖尿病和肥胖风险的策略 因此，该人群的心血管疾病必须考虑 能源消耗减少的多因素性质 这个人口。该项目已于 1997 年终止 财政年度。