PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS

不自主运动主要根据描述性运动进行分类 基础。使用生理学标准进行分类和 对运动障碍患者的研究带来了对 这些疾病的病理生理学和治疗。我们继续我们的 努力确定导致疾病发生的生理机制 阳性和阴性肌阵挛。我们已经扩展了生理学 眼阵挛-肌阵挛综合征的特点。患者的肌阵挛 已经对高谢病进行了生理学研究。我们已经研究过 生理性部分性持续性癫痫(EPC)和 这些发现与这些患者的正电子发射计算机断层扫描研究相关。 利用脑电数据同步进行随意动作和感觉诱发 电位，我们已经确定了大脑皮层模式的不同 手部肌张力障碍患者的激活。这些发现支持 正电子发射计算机断层扫描和经颅磁刺激平行研究的结果。 在一些抽动障碍患者中，我们发现了皮质的模式 类似于伴随着正常的自愿运动的激活。 我们发现了脊髓振动机制的异常 僵人综合征患者的H反射抑制 这暗示了GABA能脊髓机制的功能障碍。 遗传性亢进的患者，这是一种影响 甘氨酸受体，显示反射通路异常，被认为是 由甘氨酸能Ia中间神经元介导。少突脊髓 反射包括振动抑制、屈肌反射和皮肤反射 重度肌张力障碍患者治疗前后的静默期 鞘内注射巴氯芬正在研究中。人脑的生理特性 在不同惯性载荷下的震颤和在书写过程中的震颤在 肉毒杆菌毒素治疗前有书写震颤的患者。

Involuntary movements have been classified primarily on descriptive basis. The use of physiological criteria for the classification and study of patients with movement disorders has lead to new insights onto pathophysiology and treatment of these disorders. We continue our efforts to characterize the physiological mechanisms responsible for positive and negative myoclonus. We have expanded the physiological features of the opsoclonus-myoclonus syndrome. The myoclonus in patients with Gaucher's disease has been studied physiologically. We have studied physiologically patients with epilepsia partialis continua (EPC) and these findings have been correlated with PET studies these same patients. Using EEG dsynchronization to voluntary movements and sensory evoked potentials, we have identified differences in the patterns of cortical activation in patients with hand dystonia. These findings support findings from parallel PET and transcranial magnetic stimulation studies. In some patients with tic disorders, we have found patterns of cortical activation similar to those accompanying normal voluntary movements. We have found abnormalities of spinal cord mechanisms for vibratory inhibition of the H-reflex in patients with stiff-man syndrome (SMS) which implicates a dysfunction of GABAergic spinal cord mechanisms. Patients with hereditary hyperekplexia, a genetic disorder affecting glycine receptors, show abnormalities in reflex pathways thought to be mediated by glycinergic Ia interneurons. Oligosynaptic spinal cord reflexes including vibratory inhibition, flexor reflexes and cutaneous silent period in patients with severe dystonia before and after intrathecal baclofen are being studied. The physiological properties of tremor to various inertial loads and during writing were studied in patients with writing tremor before treatment with botulinum toxin.