Investigating the epidemiology of CFS/ME in children using the ALSPAC cohort.

使用 ALSPAC 队列研究儿童 CFS/ME 的流行病学。

• 批准号: MR/K020269/1
• 负责人: Esther Crawley
• 金额: $ 37.69万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK020269%2F1
• 关键词: Investigating; epidemiology; CFS; ME; children

CONTEXT: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in adolescents is relatively common and causes significant suffering. 1% of secondary school children miss one day a week because of CFS/ME, and 0.1% are so severely affected they are unable to attend school at all. More than half of children are bed bound at some stage, losing on average one academic year of schooling. Despite the importance of paediatric CFS/ME to those affected, their families and society, little is known about how common CFS/ME is in adolescents, what causes it and what the chances are of an adolescent recovering without treatment. In addition, little is known about the different types of CFS/ME in adolescents. If there are different types, these may suggest different causes and may need different treatments. So far, researchers have been hampered in their research in to the causes of CFS/ME because this needs reliable information about children before they develop CFS/ME.These type of studies also need to be large enough to answer these types of questions. This lack of knowledge prevents the development of interventions to prevent or treat paediatric CFS/ME in adolescents. The MRC understands the importance of understanding the mechanisms of CFS/ME in children and knowing more about the different types, and have asked researchers for studies to investigate these areas in the recent CFS/ME highlight notice.The Avon Longitudinal Study of Parents and Children (ALSPAC) provides a unique opportunity to investigate the risk factors for CFS/ME. It has enough data so that we can define CFS/ME at 3 ages (13, 16 and 17). Information on possible risk factors has been collected before the onset of CFS/ME from pregnancy to adolescence, and the number of children is sufficiently large that there is enough power to explore the causes of CFS/ME in adolescence in unprecedented detail. AIM: to describe CFS/ME in adolescence in order to understand more about the mechanisms that cause it and develop ideas on how to treat and prevent CFS/ME in this age group. OBJECTIVES1. Find out how common CFS/ME is at 15 and 17 and whether it is more common in girls or boys. Describe whether CFS/ME in adolescents gets better if untreated. 2. Investigate the different types of CFS/ME in adolescents and whether it overlaps with chronic pain disorders which have similar features. 3. Investigate risk factors for CFS/ME at 13, 16 and 17 years. We will investigate factors that have been shown to be associated with CFS/ME in either adults or children such as activity, patterns of sleep, anxiety and depression and see whether they increase the risk of developing CFS/ME or are secondary to it. 4. Investigate "maintaining factors". We will compare children who have persistent fatigue between the time points with those that recover, to understand whether there is a difference in risk factors between the two groups. POTENTIAL APPLICATIONS AND BENEFITS: Clinicians and commissioners need to know how common adolescent CFS/ME to be able to plan CFS/ME services. Knowing whether CFS/ME gets better without treatment is important for clinicians, adolescents with CFS/ME and their carers who need to decide whether to have treatment. Information on the different types of CFS/ME is important as it may help us understand more about the mechanisms involved in different types. If there are different types of CFS/ME, it is important that researchers know this so they can study the same type of illness if they need to. Understanding what the risk factors are for CFS/ME should help researchers know more about the mechanisms that cause CFS/ME and prevent recovery. This should help researchers develop better treatment and prevention trials.

慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）在青少年中相对常见，并造成严重的痛苦。1%的中学生每周因CFS/ME缺课一天，0.1%的学生受到严重影响，根本无法上学。一半以上的儿童在某个阶段卧床不起，平均损失一学年的学校教育。尽管儿科CFS/ME对受影响的人，他们的家庭和社会的重要性，但人们对CFS/ME在青少年中的常见程度，原因以及青少年在没有治疗的情况下康复的机会知之甚少。此外，对青少年不同类型的CFS/ME知之甚少。如果有不同的类型，这些可能表明不同的原因，可能需要不同的治疗。到目前为止，研究人员一直阻碍他们的研究在CFS/ME的原因，因为这需要关于儿童的可靠信息之前，他们发展CFS/ME.这些类型的研究也需要足够大，以回答这些类型的问题.这种知识的缺乏阻碍了预防或治疗青少年儿童CFS/ME的干预措施的发展。MRC了解了解儿童CFS/ME机制的重要性，并了解更多关于不同类型的信息，雅芳亲子纵向研究（Avon Longitudinal Study of Parents and Children，ALSPAC）提供了一个独特的机会来研究CFS/ME的危险因素，它有足够的数据，使我们可以在3个年龄段定义CFS/ME。（13、16和17）。在CFS/ME从怀孕到青春期发病之前，已经收集了有关可能的危险因素的信息，并且儿童数量足够大，有足够的力量以前所未有的细节探索青春期CFS/ME的原因。目的：描述青春期的CFS/ME，以便更多地了解导致它的机制，并制定如何在这个年龄组治疗和预防CFS/ME的想法。1.了解CFS/ME在15岁和17岁时的常见程度，以及它在女孩或男孩中是否更常见。描述青少年CFS/ME如果不治疗是否会好转。2.调查青少年CFS/ME的不同类型，以及它是否与具有相似特征的慢性疼痛疾病重叠。3.调查13、16和17岁时CFS/ME的风险因素。我们将调查已被证明与成人或儿童CFS/ME相关的因素，如活动，睡眠模式，焦虑和抑郁，看看它们是否会增加CFS/ME的风险或继发于它。4.调查“维持因素”。我们将比较在时间点之间持续疲劳的儿童与恢复的儿童，以了解两组之间的风险因素是否存在差异。潜在的应用和好处：临床医生和专员需要知道如何常见的青少年CFS/ME能够计划CFS/ME服务。了解CFS/ME是否在没有治疗的情况下变得更好对于临床医生，CFS/ME青少年及其需要决定是否接受治疗的照顾者非常重要。有关不同类型CFS/ME的信息很重要，因为它可以帮助我们更多地了解不同类型所涉及的机制。如果有不同类型的CFS/ME，重要的是研究人员知道这一点，这样他们就可以在需要时研究同一类型的疾病。了解CFS/ME的风险因素应该有助于研究人员更多地了解导致CFS/ME和阻止恢复的机制。这将有助于研究人员开发更好的治疗和预防试验。

项目成果

Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.

• DOI: 10.1136/archdischild-2017-314138
• 发表时间: 2018-06
• 期刊: Archives of disease in childhood
• 影响因子: 5.2
• 作者: Collin SM;Norris T;Deere KC;Jago R;Ness AR;Crawley E
• 通讯作者: Crawley E

Obesity in adolescents with chronic fatigue syndrome: an observational study.

慢性疲劳综合征青少年的肥胖症：一项观察性研究。

• DOI: 10.1136/archdischild-2016-311293
• 发表时间: 2017-01
• 期刊: Archives of disease in childhood
• 影响因子: 5.2
• 作者: Norris T;Hawton K;Hamilton-Shield J;Crawley E
• 通讯作者: Crawley E

Non-specific abdominal pain in childhood.

儿童时期非特异性腹痛。

• DOI: 10.1136/archdischild-2015-309383
• 发表时间: 2016
• 期刊: Archives of disease in childhood
• 影响因子: 5.2
• 作者: Crawley E

Chronic Fatigue Syndrome and Chronic Widespread Pain in Adolescence: Population Birth Cohort Study.

• DOI: 10.1016/j.jpain.2016.10.016
• 发表时间: 2017-03
• 期刊: The journal of pain
• 作者: Norris T;Deere K;Tobias JH;Crawley E
• 通讯作者: Crawley E

Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts.

• DOI: 10.1136/bmjopen-2015-008830
• 发表时间: 2015-10-28
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Collin SM;Nuevo R;van de Putte EM;Nijhof SL;Crawley E
• 通讯作者: Crawley E