COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

描述：(申请人描述) 艾滋病恶性蜡染(AMB)成立于1994年，自1995年以来 由五个站点组成：纽约大学布鲁克林分校、俄亥俄州立大学、加州大学旧金山分校、加州大学洛杉矶分校和乔治华盛顿大学。 AMB是一项全国性的资源，反映了 标本中HIV病的恶性病变。因为AMB的科学家 积极参与艾滋病发病机制的研究-- 相关的恶性肿瘤，AMB对科学和治疗有反应 艾滋病的研究进展。目前，AMB有12,688名个人 标本27类。体液、细胞和组织标本， 以及相关的临床信息，均可提供给合格的 世界各地的研究人员。根据数据，18名不同的调查人员收到了 900多个标本在对它们的信件进行了严格评估后 由独立研究和评估决策小组提供的意向(LOITs) (REDP)该领域的专家。 目前的重新竞争提案结合了来自所有ABC的信息 会员站点，以及成绩、未来计划、目标和预算 来自各个站点的预测。AMB的主要目标是：1)建立 一个将维护国家数据库的中央业务办公室 并协调AMB成员的活动，外部来源 标本，如艾滋病相关恶性肿瘤联盟(AMC)和 妇女机构间艾滋病毒研究和申请者调查；2)扩大 AMB将作为大型肿瘤临床的标本库 和流行病财团，最终导致采购他们的 标本；3)通过以下方式提高AMB的可见性和扩大其用途 调查人员；以及4)进一步开发个人会员网站计划 增加标本采集量。 俄亥俄州、德克萨斯州、伊利诺伊州、佐治亚州和田纳西州的俄亥俄州-AMB联盟， 建议通过从患者那里购买组织来实现AMB的关键目标 美国中部地区的地理位置和人口。十五 六个主要城市的地点将提供新鲜标本收集，以及 患者关于治疗方案的临床数据以及危重患者 访问与石蜡包埋的HIV相关的大型病理档案 恶性肿瘤。这些HIV血清阳性的恶性肿瘤的特殊集合 匹配的散发性恶性肿瘤和移植相关的 恶性肿瘤，部分恶性肿瘤的银行DNA前方显微解剖 和特征良好的卡波西肉瘤细胞系将可用于 全球的过渡性癌症研究人员。存储库函数将是 提供给选定的艾滋病毒/艾滋病治疗小组。

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Batik (AMB) was established in 1994, and since 1995 has been composed of five sites: SUNY-Brooklyn, OSU, UCSF, UCLA, and GWU. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the pathogenesis of AIDS- related malignancies, the AMB is responsive to scientific and therapeutic advances in HIV disease. Current, the AMB contains 12, 688 individual specimens in 27 categories. The fluids, cells, and tissue specimens, along with associated clinical information, are available to qualified researcher worldwide. To data, 18 different investigators have received over 900 specimens following critical evaluation of their Letters of Intent (LOITs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This Current re-competition proposal combines information from all ABC member sites, as well as accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish a centralized Operations Office that will maintain the national database and coordinate activities of the AMB members, external sources of specimens such as the AIDS-related Malignancy Consortium (AMC) and the Women's Interagency HIV study, and applicant investigators; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens; 3) to increase visibility and broaden the use of the AMB by investigators; and 4) to further develop individual member site programs to increase specimen acquisition. The OSU-AMB Consortium, Ohio, Texas, Illinois, Georgia, and Tennessee, proposes to fulfill the key AMB goals by procuring tissue from patients in the geographic and population mid-region of the United State. Fifteen sites in six key cities will provide collection of fresh specimens, and clinical data from patients on treatment protocols as well as critical access to large pathology archives with paraffin-embedded HIV-associated malignancies. Special collections of these HIV seropositive malignancies with matched sporadic malignancies and transplantation-associated malignancies, banked DNA front microdissections of selected malignancies and well characterized Kaposi's Sarcoma cell lines will be available to transitional cancer researchers worldwide. Repository functions will be available to selected HIV/AIDS treatment groups.