COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

HIV 阳性恶性肿瘤合作组织库

• 批准号: 7067158
• 负责人: LEONA W AYERS
• 金额: $ 53.85万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-12 至 2008-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7067158
• 关键词: AIDS related neoplasm /cancer; HIV infections; Kaposi' s sarcoma; biopsy; cancer information system; cancer registry /resource; clinical research; cooperative study; data management; histopathology; human genetic material tag; human subject; human tissue; information dissemination; lymphoma; opportunistic infections; patient oriented research; postmortem; tissue resource /registry; virus related neoplasm /cancer

DESCRIPTION (provided by applicant): The AIDS and Cancer Specimen Bank (ACSB), established in 1994 by the NCI Division of Cancer Treatment and Diagnosis (OD-DCDT) to promote research into the pathogenesis and treatment of AIDS-related malignancies, provides HIV- associated malignant tissues and clinical outcome data to approved researchers. The Ohio State University ACSB Consortium (OSU-ACSB) with sites in Ohio, Illinois, Tennessee, Georgia and Texas proposes to assist the national ACSB by procurement of HIV infected tissues and associated clinical outcomes from a 17 state mid-region of the United States where 40% of the USA population, 32% of persons living with HIV/AIDS and25 % of all AIDS/HIV cases are located. Collections in two African countries, Kenya and Uganda, are proposed to increase access to HIV-associated malignancies. Over 12,483 samples or approximately 23% of ACSB samples have been collected. Specific OSU-ACSB aims are: 1) to procure fresh AIDS-associated malignant tissues, cells and fluids from clinical cases and donated samples from association with NCI funded clinical trial groups such as "Oral Chemotherapy in AIDS-related NHL in Africa" (1R01 CA83528-01) with clinical samples banked at proposed African sites until transported to the OSU-ACSB; 2) to preserve archived paraffin embedded HIV/AIDS tissues with emphasis on providing tissue micro arrays (TMAs) to approved investigators. TMAs preserve HIV infected tissues from the beginning of the HIV epidemic and facilitate the study of selected targets in large populations of tissues. The TMAs are supported by a custom tissue array data system (TADS) developed by the OSU-ACSB using evolving standards of the national Association for Pathology Informatics (API). TADS provides approved investigators with de-identified patient clinical data, TMA block pedigree, quality control data including tissue array H & E digital images, and quality assessment by tissue morphometrics and selected tests. Analysis of investigator tissue array tests will be available using OSU-ACSB sophisticated image acquisition and analysis equipment/software; 3) to work with NCI sponsored tissue resources such as the CHTN to optimize NCI funds for tissue service to cancer researchers and clinical trial groups; 4)to participate with the OD-DCTD, ACSB Steering Committee, Central Operations and Data Coordination Center, and all ACSB Consortia to increase banked specimens, to promote utilization of the ACSB and to work with approved researchers to provide timely and quality materials for investigations.

描述（由申请人提供）： 艾滋病和癌症标本库（ACSB），由NCI于1994年建立 癌症治疗和诊断部门（OD-DCDT），以促进研究， 艾滋病相关恶性肿瘤的发病机制和治疗，提供艾滋病毒- 相关恶性组织和临床结局数据，以获得批准 研究人员俄亥俄州州立大学ACSB联盟（OSU-ACSB） 在俄亥俄州，伊利诺伊州，田纳西州，格鲁吉亚和得克萨斯州建议协助 国家ACSB通过采购HIV感染组织和相关临床 美国中部17个州的结果，其中40%的美国人 艾滋病毒/艾滋病感染者和所有艾滋病/艾滋病毒病例的25% 被定位。在两个非洲国家，肯尼亚和乌干达， 建议增加获得艾滋病毒相关恶性肿瘤的机会。超过12，483人 已收集了约23%的ACSB样本。具体 OSU-ACSB的目标是：1）获得新鲜的艾滋病相关恶性组织， 来自临床病例的细胞和液体，以及与 NCI资助的临床试验小组，如“口服化疗在艾滋病相关 非洲NHL”（1 R 01 CA 83528 -01），临床样本储存在拟定的 非洲遗址，直到运送到OSU-ACSB; 2）保存存档 石蜡包埋的HIV/AIDS组织，重点是提供组织显微镜 阵列（TMAs）提供给经批准的研究者。TMA保存HIV感染组织 从艾滋病毒流行开始，并促进对选定的 靶点在大量组织中。TMA由自定义的 组织阵列数据系统（TADS）由OSU-ACSB开发， 国家病理学信息学协会（API）的标准。TADS 为批准的研究者提供去识别的患者临床数据，TMA 组织块谱系，质量控制数据，包括组织阵列H & E数字 图像，以及通过组织形态测量学和选择的测试进行质量评估。 将使用OSU-ACSB对研究者组织阵列检测进行分析 先进的图像采集和分析设备/软件; 3）工作 与NCI赞助的组织资源，如CHTN，以优化NCI的资金， 为癌症研究人员和临床试验小组提供组织服务; 4） 参与OD-DCTD、ACSB指导委员会、中央运营和 数据协调中心和所有ACSB联盟增加库存标本， 促进ACSB的利用，并与经批准的研究人员合作， 为调查提供及时和高质量的材料。