COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

HIV 阳性恶性肿瘤合作组织库

• 批准号: 7441181
• 负责人: LEONA W AYERS
• 金额: $ 72.96万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-12 至 2008-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7441181
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Area; Bioinformatics; Biological Preservation; Clinical; Clinical Trials[{..}] Cancer Treatment; Collaborations; Consultations; DNA; Data; Diagnostic; Distant; Facility Construction Funding Category; Funding; HIV Infections; Health; Human; Image; Internet; Kenya; Laboratories; Location; Lymphoma; Malignant - descriptor; Malignant Neoplasms; Methods; Microscopy; National Cancer Institute; Ohio; Operative Surgical Procedures; Pathology; Phenotype; Process; Proteins; Recommendation; Regulation; Research; Research Personnel; Resources; Specimen; Staining method; Stains; Structure; Tennessee; Tissue Banks; Tissue Fixation; Tissue Microarray; Tissues; Translations; Tumor Tissue; Uganda; Universities; Visual; Work; biomedical informatics; cancer Biomedical Informatics Grid; digital; digital imaging; follow-up; human tissue; improved; innovation; laboratory facility; programs; sample collection; tissue resource

{\rtf1\ansi\ansicpg1252\deff0\deflang1033{\fonttbl{\f0\fswiss\fcharset0 Arial;}} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs21 The AIDS and Cancer Specimen Resource (ACSR) of the National Cancer Institutes (NCI) AIDS Malignancy\par Program, provides HIV/AIDS-related malignant tissues and data to funded/approved cancer researchers to\par promote a global understanding of the relationships between HIV infection and certain cancers. The Mid\par Region ACSR (MR-ACSR) consortium, including: The Ohio State University (OSU), Emory University, Rush\par University, University of Tennessee, Memphis, and East African affiliates in Uganda and Kenya, proposes to\par (specific aim 1) maintain a mid-region ACSR (MR-ACSR) biorepository with affiliates that is compliant with all\par ACSR rules and recommendations including the NCI Best Practices for Biospecimen Resources and\par applicable federal regulations and is adequately structured with an Operations Office to perform the\par principal tasks of collecting, enhancing, storing, and distributing HIV-related, quality assured human\par tumor tissue with associated clinical, pathological, visual and demographic data to approved\par investigators. To assure best use of these resources the MR-ACSR proposes to (specific aim 2) collaborate\par with ACSR regional biorepositories, NCI AIDS Malignancy Program (AMP) and other NCI AIDS related\par malignancy and cancer biorepository programs and The Ohio State University Department of Pathology's\par Human Tissue Resource Network (HTRN) to leverage quality specimen and data availability for translational\par research in area of HIV/AIDS-related malignancies. To accomplish the overall objectives of the NCI to\par promote good health, the MR-ACSR must (specific aim 3) develop original and innovative programs to\par improve the quality, availability and relevance of biospecimens and associated data using the laboratory\par facilities and specimen resources of the MR-ACSR consortium including the East African affiliates, The Ohio\par State University Department of Pathology's HTRN and the Department of Biomedical Informatics caBIG\par project. MR-ACSR proposes the deployment of a new tissue fixation method to improve preservation of\par RNA, DNA and tissue proteins for research tissues. Tissue microarray (TMA) construction can be deployed\par using a "field" construction format that facilitates diagnostic specimen collection in resource constrained\par locations. We propose to facilitate the tissue phenotyping of lymphoma (NHL) in sub-Saharan Africa using\par this TMA format with follow up distant processing and immunohistochemical staining. The MR-ACSR also\par has a supporting digital microscopy facility for remote visual Internet consultation using digitized images of\par tissue for data sharing with our collaborators in East Africa, particularly related to diagnostic consultation and\par review of pathology tissues in cancer clinical treatment trials. Finally, to make the best use of visual data and\par distant collaboration, the MR ACSR proposes to work with the developers of caGrid as a clinical resource for\par digital image data.\fs20\par \par }

{\fnSimHei\bord1\shad1\pos（200，288）} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs21美国国家癌症研究所（NCI）的艾滋病和癌症标本资源（ACSR）艾滋病标本\par 计划，提供艾滋病毒/艾滋病相关的恶性组织和数据，以资助/批准的癌症研究人员\par 促进全球对艾滋病毒感染和某些癌症之间关系的了解。Mid\par 区域ACSR（MR-ACSR）联合体，包括：俄亥俄州州立大学（OSU）、埃默里大学、拉什\帕尔 田纳西大学，孟菲斯，以及乌干达和肯尼亚的东非分支机构，建议\par （具体目标1）维持一个中部地区ACSR（MR-ACSR）生物储存库，其附属机构符合所有\par ACSR规则和建议，包括NCI生物标本资源最佳实践和\par 适用的联邦法规，并有适当的运营办公室来执行 主要任务是收集、增强、储存和分发与艾滋病毒有关的、有质量保证的人类信息， 肿瘤组织以及相关的临床、病理学、视觉和人口统计学数据， investigators.为确保这些资源得到最佳利用，MR-ACSR建议（具体目标2）与\par 与ACSR区域生物储存库、NCI艾滋病预防计划（AMP）和其他NCI艾滋病相关\par 恶性肿瘤和癌症生物储存计划和俄亥俄州州立大学病理学系的\par 人类组织资源网络（HTRN）利用高质量的标本和数据， 艾滋病毒/艾滋病相关恶性肿瘤领域的研究。为了实现NCI的总体目标， 为了促进健康，MR-ACSR必须（具体目标3）开发原创和创新的项目， 利用实验室\par提高生物标本和相关数据的质量、可用性和相关性 MR-ACSR联合体的设施和样本资源，包括东非分公司、俄亥俄州\par 州立大学病理学系HTRN和生物医学信息学系caBIG\par 项目MR-ACSR提出了一种新的组织固定方法的部署，以改善保留的部分 用于研究组织的RNA、DNA和组织蛋白。组织微阵列（TMA）构建可以部署在 使用“字段”构造格式，以便于在资源受限的环境中收集诊断样本 地点我们建议使用免疫组织化学方法来促进撒哈拉以南非洲淋巴瘤（NHL）的组织表型分析。 这种TMA格式与后续的远程处理和免疫组织化学染色。MR-ACSR还 有一个支持数字显微镜设施，用于远程视觉互联网咨询，使用数字化图像的\par 与我们在东非的合作者共享数据，特别是与诊断咨询和\par相关的数据。 癌症临床治疗试验中病理组织的综述。最后，为了充分利用可视化数据和\par 远程合作，MR ACSR建议与caGrid的开发人员合作，作为\par的临床资源 数字图像数据。fs20\par \par }