Collaborative Human Tissue Network (CHTN)

描述（由申请人提供）：本提案组织了俄亥俄州综合癌症中心（CCC）的大量资源和经验，以通过美国国家癌症研究所（NCI）合作人体组织网络（CHTN）为基础和早期转化癌症研究提供病理学残留生物材料。目标1。与Case Western Reserve University的Case Comprehensive Cancer Center; Seidman Cancer Center，University Hospitals，Case Medical Center合作，向科学界提供前瞻性采集的、经鉴定的高质量残留癌前病变、恶性、良性、病变和正常生物标本及相关人口统计学数据; Taussig癌症研究所，克利夫兰诊所，克利夫兰，俄亥俄州和俄亥俄州州立大学综合癌症中心（OSU-CCC），亚瑟G。James癌症医院和Richard J. Solove研究所，哥伦布，俄亥俄州。该俄亥俄州联盟自2001年以来一直合作，并已证明生物标本和相关数据的可用性，以回应研究者的要求。目标2.在研究方案制定和项目部署期间，随时为感兴趣的研究者或需要帮助的研究者提供个人咨询和实验室服务。专门的病理学家可与潜在的研究者就研究需求进行咨询，俄勒冈州立大学有一个有组织的人类组织资源网络（HTRN），由病理学家Leona W.艾尔斯医学博士，用于研究咨询，HTRN组织了研究服务和实验室网络，从申请批准到收到所需生物材料，与研究者合作（http：htrn.osu.edu）。常规组织学和特殊研究服务，如数字成像，数字形态分析，RNA/DNA分离和TMA。目标3。为生物标本科学和生物标本研究管理做出贡献，以提高研究中生物标本使用的质量和生产率。艾尔斯博士和工作人员定期参加生物标本专业会议，并在最近以生物标本和癌症为重点的国家和国际会议上贡献了18份摘要、海报和讲台演讲。目标4。与国家CHTN和NCI项目官员合作，协调CHTN组织，开发CHTN小组项目，改善共享的IT资源，并教育调查员和社区有关CHTN资源。我们的提案有资格的参与者在CHTN委员会和小组委员会任职，为CHTN的专业发展做出贡献，并为非专业社区利益提供倡导者。

DESCRIPTION (provided by applicant): This proposal organizes the considerable resources and experience of Ohio Comprehensive Cancer Centers (CCC) in consortium to make available pathology remnant biomaterials for basic and early translational cancer research through the National Cancer Institute (NCI) Collaborative Human Tissue Network (CHTN). Aim 1. To provide prospectively procured, investigator-defined, high quality remnant pre-malignant, malignant, benign, diseased and normal biospecimens with associated demographic data to the scientific community in consortium with the Case Comprehensive Cancer Center, Case Western Reserve University; Seidman Cancer Center, University Hospitals, Case Medical Center; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH and The Ohio State University Comprehensive Cancer Center (OSU-CCC), The Arthur G. James Cancer Hospital & Richard J. Solove Research Institute, Columbus, OH. This Ohio consortium has worked together since 2001 and has demonstrated biospecimen and associated data availability to respond to investigator requests. Aim 2. To provide individual consultation and laboratory services to interested investigators or investigators in need of assistance at any time during their research protocol development and project deployment. Dedicated pathologists are available to consult with potential investigators regarding research needs and OSU has an organized Human Tissue Resource Network (HTRN) with a biospecimen procurement program headed by pathologist, Leona W. Ayers, M.D., for research consultation and the HTRN organized network of research services and laboratories to work with investigators from application approval to receipt of requested biomaterials (http://htrn.osu.edu). Routine histology and special research services such as digital imaging, digital morphometric analysis, RNA/DNA isolation and TMAs are available. Aim 3. To contribute to biospecimen science and biospecimen research management to increase the quality and productivity of biospecimen use in research. Dr. Ayers and staff regularly attend biospecimen professional meetings and have contributed 18 abstracts, poster and podium presentations, at recent biospecimen and cancer focused national and international meetings. Aim 4. To work with the national CHTN and NCI program officers to harmonize the CHTN organization, to develop CHTN group projects, to improve shared IT resources and to educate the investigator and lay communities about CHTN resources. Our proposal has well qualified participants to serve on CHTN committees and subcommittees, contribute to the professional development of the CHTN and to provide an advocate to serve lay community interests.