Mid-Region AIDS and Cancer Specimen Resource Consortium

中部地区艾滋病和癌症标本资源联盟

• 批准号: 7687968
• 负责人: LEONA W AYERS
• 金额: $ 60.31万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-12 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687968
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Area; Bioinformatics; Biological Preservation; Clinical; Clinical Treatment; Collaborations; Consultations; DNA; Data; Diagnostic; Distant; Funding; HIV Infections; Health; Human; Image; Internet; Kenya; Location; Lymphoma; Malignant - descriptor; Malignant Neoplasms; Methods; Microscopy; National Cancer Institute; Ohio; Operative Surgical Procedures; Pathology; Phenotype; Process; Proteins; Recommendation; Regulation; Research; Research Personnel; Resources; Specimen; Staining method; Stains; Structure; Tennessee; Tissue Fixation; Tissue Microarray; Tissues; Translational Research; Tumor Tissue; Uganda; Universities; Visual; Work; biobank; biomedical informatics; caGrid; cancer Biomedical Informatics Grid; cancer specimen resource; data sharing; digital; digital imaging; follow-up; human tissue; improved; innovation; laboratory facility; programs; sample collection; tissue resource; treatment trial

DESCRIPTION (provided by applicant): The AIDS and Cancer Specimen Resource (ACSR) of the National Cancer Institutes (NCI) AIDS Malignancy Program provides HIV/AIDS-related malignant tissues and data to funded/approved cancer researchers to promote a global understanding of the relationships between HIV infection and certain cancers. The Mid Region ACSR (MR-ACSR) consortium, including The Ohio State University (OSU), Emory University, Rush University, University of Tennessee, Memphis, and East African affiliates in Uganda and Kenya, proposes to (specific aim 1) maintain a mid-region ACSR (MR-ACSR) biorepository with affiliates that is compliant with all ACSR rules and recommendations including the NCI Best Practices for Biospecimen Resources and applicable federal regulations and is adequately structured with an Operations Office to perform the principal tasks of collecting, enhancing, storing, and distributing HIV-related, quality assured human tumor tissue with associated clinical, pathological, visual and demographic data to approved investigators. To assure best use of these resources, the MR-ACSR proposes to (specific aim 2) collaborate with ACSR regional biorepositories, NCI AIDS Malignancy Program (AMP) and other NCI AIDS related malignancy and cancer biorepository programs and The Ohio State University Department of Pathology's Human Tissue Resource Network (HTRN) to leverage quality specimen and data availability for translational research in the area of HIV/AIDS-related malignancies. To accomplish the overall objectives of the NCI to promote good health, the MR-ACSR must (specific aim 3) develop original and innovative programs to improve the quality, availability and relevance of biospecimens and associated data using the laboratory facilities and specimen resources of the MR-ACSR consortium including the East African affiliates, The Ohio State University Department of Pathology's HTRN and the Department of Biomedical Informatics caBIG project. MR-ACSR proposes the deployment of a new tissue fixation method to improve preservation of RNA, DNA and tissue proteins for research tissues. Tissue microarray (TMA) construction can be deployed using a "field" construction format that facilitates diagnostic specimen collection in resource constrained locations. We propose to facilitate the tissue phenotyping of lymphoma (NHL) in sub-Saharan Africa using this TMA format with follow up distant processing and immunohistochemical staining. The MR-ACSR also has a supporting digital microscopy facility for remote visual Internet consultation using digitized images of tissue for data sharing with our collaborators in East Africa, particularly related to diagnostic consultation and review of pathology tissues in cancer clinical treatment trials. Finally, to make the best use of visual data and distant collaboration, the MR-ACSR proposes to work with the developers of caGrid as a clinical resource for digital image data.

描述(由申请人提供)：国家癌症研究所(NCI)艾滋病恶性项目的艾滋病和癌症标本资源(ACSR)向获得资助/批准的癌症研究人员提供与艾滋病毒/艾滋病相关的恶性组织和数据，以促进全球对艾滋病毒感染和某些癌症之间的关系的了解。中部地区ACSR(MR-ACSR)联盟，包括俄亥俄州立大学(OSU)、埃默里大学、拉什大学、田纳西大学、孟菲斯大学和东非在乌干达和肯尼亚的附属机构，提议(具体目标1)维护一个中部地区ACSR(MR-ACSR)生物信息库，其附属机构符合所有ACSR规则和建议，包括NCI生物医学资源最佳实践和适用的联邦法规，并与运营办公室充分构建，以执行主要任务，收集、增强、存储和向经批准的研究人员分发与艾滋病毒相关的、质量有保证的人类肿瘤组织以及相关的临床、病理、视觉和人口统计数据。为了确保这些资源的最佳利用，MR-ACSR建议(具体目标2)与ACSR地区生物信息库、NCI艾滋病恶性疾病计划(AMP)和其他NCI艾滋病相关恶性肿瘤和癌症生物信息库计划以及俄亥俄州立大学病理系人类组织资源网络(HTRN)合作，利用高质量的样本和数据可用性进行艾滋病毒/艾滋病相关恶性肿瘤领域的转化研究。为了实现NCI促进健康的总体目标，MR-ACSR必须(具体目标3)利用MR-ACSR联盟的实验室设施和标本资源(包括东非附属机构、俄亥俄州立大学病理学系的HTRN和生物医学信息学系caBIG项目)开发原创和创新的计划，以提高生物标本和相关数据的质量、可用性和相关性。MR-ACSR建议部署一种新的组织固定方法，以改善研究组织的RNA、DNA和组织蛋白质的保存。组织微阵列(TMA)构建可以使用便于在资源受限的位置收集诊断样本的“现场”构建格式来部署。我们建议使用这种TMA格式来促进撒哈拉以南非洲淋巴瘤(NHL)的组织表型，并进行后续的远程处理和免疫组织化学染色。MR-ACSR还拥有支持远程视觉互联网会诊的数字显微镜设施，使用组织的数字化图像与我们在东非的合作者共享数据，特别是与癌症临床治疗试验中的诊断会诊和病理组织审查相关的数据。最后，为了最大限度地利用可视数据和远程协作，MR-ACSR建议与caGrid的开发者合作，作为数字图像数据的临床资源。