COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

描述：（申请人的描述） 艾滋病治疗蜡染（AMB）成立于1994年，自1995年以来， 由五个站点组成：SUNY-Brooklyn，OSU，UCSF，UCLA和GWU。 AMB是一种反映历史的国家资源， 样本中的HIV疾病的恶性肿瘤。因为电磁轴承的科学家们 也积极参与艾滋病发病机理的研究， 相关的恶性肿瘤，AMB是响应科学和治疗 艾滋病的进展。目前，AMB包含12，688名个人 27个类别的标本。体液细胞和组织样本沿着 以及相关临床信息，可供合格人员使用 世界各地的研究员。根据数据，18名不同的调查人员收到了 900多个标本经过严格的评估，他们的信， 独立研究和评估决策小组的意向（LOIT） （REDP）的专家。 目前的重新竞争提案结合了所有ABC的信息 成员站点，以及成就、未来计划、目标和预算 个别网站的预测。AMB的主要目标是：1）建立 中央业务办公室，负责维护国家数据库 并协调AMB成员的活动， 例如艾滋病相关的艾滋病联盟（AMC）和 妇女的机构间艾滋病毒研究，和申请调查员; 2）扩大 AMB作为大型肿瘤临床标本库 和流行病学财团，最终导致采购他们的 标本; 3）提高知名度，扩大AMB的使用范围， 研究者;以及4）进一步发展个别成员研究中心计划 以增加样本采集。 OSU-AMB联盟，俄亥俄州，得克萨斯州，伊利诺伊州，格鲁吉亚和田纳西州， 建议通过从患者中获取组织来实现AMB的关键目标， 美国的地理和人口中心。十五 六个主要城市的地点将提供新鲜标本的采集， 来自患者治疗方案的临床数据以及关键的 访问石蜡包埋的HIV相关的大型病理档案， 恶性肿瘤。这些艾滋病毒血清阳性恶性肿瘤的特别收藏 与之匹配的散发性恶性肿瘤和移植相关的 恶性肿瘤，选定恶性肿瘤的库DNA前端显微切割 和良好表征的卡波西肉瘤细胞系将可用于 世界各地的癌症研究者。存储库功能将 向选定的艾滋病毒/艾滋病治疗群体提供。

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Batik (AMB) was established in 1994, and since 1995 has been composed of five sites: SUNY-Brooklyn, OSU, UCSF, UCLA, and GWU. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the pathogenesis of AIDS- related malignancies, the AMB is responsive to scientific and therapeutic advances in HIV disease. Current, the AMB contains 12, 688 individual specimens in 27 categories. The fluids, cells, and tissue specimens, along with associated clinical information, are available to qualified researcher worldwide. To data, 18 different investigators have received over 900 specimens following critical evaluation of their Letters of Intent (LOITs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This Current re-competition proposal combines information from all ABC member sites, as well as accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish a centralized Operations Office that will maintain the national database and coordinate activities of the AMB members, external sources of specimens such as the AIDS-related Malignancy Consortium (AMC) and the Women's Interagency HIV study, and applicant investigators; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens; 3) to increase visibility and broaden the use of the AMB by investigators; and 4) to further develop individual member site programs to increase specimen acquisition. The OSU-AMB Consortium, Ohio, Texas, Illinois, Georgia, and Tennessee, proposes to fulfill the key AMB goals by procuring tissue from patients in the geographic and population mid-region of the United State. Fifteen sites in six key cities will provide collection of fresh specimens, and clinical data from patients on treatment protocols as well as critical access to large pathology archives with paraffin-embedded HIV-associated malignancies. Special collections of these HIV seropositive malignancies with matched sporadic malignancies and transplantation-associated malignancies, banked DNA front microdissections of selected malignancies and well characterized Kaposi's Sarcoma cell lines will be available to transitional cancer researchers worldwide. Repository functions will be available to selected HIV/AIDS treatment groups.