COOPERATIVE TISSUE BANK OF HIV POSITIVE MALIGNANCIES

HIV 阳性恶性肿瘤合作组织库

• 批准号: 6376132
• 负责人: LEONA W AYERS
• 金额: $ 68.38万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-12 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376132
• 关键词: AIDS related neoplasm /cancer; HIV infections; Kaposi's sarcoma; biopsy; cancer information system; cancer registry /resource; clinical research; cooperative study; data management; human genetic material tag; human subject; human tissue; information dissemination; lymphoma; opportunistic infections; postmortem; tissue resource /registry; virus related neoplasm /cancer

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Batik (AMB) was established in 1994, and since 1995 has been composed of five sites: SUNY-Brooklyn, OSU, UCSF, UCLA, and GWU. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the pathogenesis of AIDS- related malignancies, the AMB is responsive to scientific and therapeutic advances in HIV disease. Current, the AMB contains 12, 688 individual specimens in 27 categories. The fluids, cells, and tissue specimens, along with associated clinical information, are available to qualified researcher worldwide. To data, 18 different investigators have received over 900 specimens following critical evaluation of their Letters of Intent (LOITs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This Current re-competition proposal combines information from all ABC member sites, as well as accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish a centralized Operations Office that will maintain the national database and coordinate activities of the AMB members, external sources of specimens such as the AIDS-related Malignancy Consortium (AMC) and the Women's Interagency HIV study, and applicant investigators; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens; 3) to increase visibility and broaden the use of the AMB by investigators; and 4) to further develop individual member site programs to increase specimen acquisition. The OSU-AMB Consortium, Ohio, Texas, Illinois, Georgia, and Tennessee, proposes to fulfill the key AMB goals by procuring tissue from patients in the geographic and population mid-region of the United State. Fifteen sites in six key cities will provide collection of fresh specimens, and clinical data from patients on treatment protocols as well as critical access to large pathology archives with paraffin-embedded HIV-associated malignancies. Special collections of these HIV seropositive malignancies with matched sporadic malignancies and transplantation-associated malignancies, banked DNA front microdissections of selected malignancies and well characterized Kaposi's Sarcoma cell lines will be available to transitional cancer researchers worldwide. Repository functions will be available to selected HIV/AIDS treatment groups.

描述：（申请人的描述） 艾滋病恶性肿瘤蜡染组织 (AMB) 成立于 1994 年，自 1995 年起 由五个校区组成：纽约州立大学布鲁克林分校、俄勒冈州立大学、加州大学旧金山分校、加州大学洛杉矶分校和乔治华盛顿大学。 AMB 是反映国家历史的国家资源 标本中艾滋病毒疾病的恶性肿瘤。因为 AMB 的科学家 他们自己积极参与艾滋病发病机制的研究 相关恶性肿瘤，AMB 对科学和治疗做出反应 艾滋病毒疾病的进展。目前，AMB 包含 12, 688 名个人 标本分为27类。液体、细胞和组织样本，以及 以及相关的临床信息，可供合格的人员使用 全球研究员。数据显示，18 位不同的研究人员收到了 对 900 多个样本进行严格评估后 独立研究和评估决策小组的意图 (LOIT) (REDP) 该领域的专家。 当前的复赛提案结合了所有 ABC 的信息 会员网站以及成就、未来计划、目标和预算 来自各个站点的预测。 AMB 的主要目标是： 1) 建立 一个维护国家数据库的集中运营办公室 协调 AMB 成员的活动、外部资源 例如艾滋病相关恶性肿瘤联盟 (AMC) 和 妇女机构间艾滋病毒研究和申请调查员； 2）扩大 AMB 作为大型肿瘤临床样本库 和流行病学联盟，最终导致采购他们的 标本； 3）提高AMB的知名度并扩大AMB的使用 调查员； 4) 进一步开发个人会员网站计划 以增加标本采集。 OSU-AMB 联盟，俄亥俄州、德克萨斯州、伊利诺伊州、佐治亚州和田纳西州， 提议通过从患者那里采购组织来实现 AMB 的关键目标 美国中部地区的地理和人口。十五 六个主要城市的站点将提供新鲜标本的采集，以及 来自患者的治疗方案以及关键临床数据 访问石蜡包埋的 HIV 相关大型病理档案 恶性肿瘤。这些 HIV 血清阳性恶性肿瘤的特别收藏 与相匹配的散发性恶性肿瘤和移植相关的 恶性肿瘤，选定恶性肿瘤的 DNA 前端显微切割 和经过充分表征的卡波西肉瘤细胞系将可用于 全世界的过渡性癌症研究人员。存储库功能将是 可供选定的艾滋病毒/艾滋病治疗群体使用。