The developing human pain connectome and brain dynamics of infant pain: sex differences, pain history and skin-to-skin care

人类疼痛连接组的发育和婴儿疼痛的大脑动力学：性别差异、疼痛史和皮肤护理

• 批准号: MR/S003207/1
• 负责人: Lorenzo Fabrizi
• 金额: $ 123.44万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS003207%2F1
• 关键词: developing; human; pain; connectome; brain

Many infants need neonatal care at birth, either because they have been born prematurely or because they are unwell. Some of the most premature and unwell babies can spend months in hospital where they undergo numerous clinical procedures, many of which are tissue breaking and likely to be painful. Despite efforts to reduce the number of procedures and handling, the burden to these vulnerable individuals is considerable, particularly as they occur at a critical phase of brain development, when connections are forming between different brain regions. The developing brain requires sensory stimulation to develop normally, but if this stimulation is exaggerated or applied at inappropriate developmental stages, it can cause permanent harm. Indeed, repeated early exposure to painful procedures is associated with lasting adverse changes to the brain. The aim of this project is to understand how pain is processed in the human infant brain. We will map the structural and functional development of the brain circuits that are necessary to process pain and investigate how these are affected by the repeated tissue-damaging procedures of hospital stay. We will establish whether these circuits develop differently in males and females. Moreover, as the experience of pain is highly dependent upon what is already going on in the brain and what happens around us, we will explore how ongoing brain activity influences the response to a painful stimulus and how we can manipulate these processes with non-pharmacological interventions, such as caregiver skin-to-skin care, to reduce the pain experienced. This research project will provide the knowledge we need to alleviate infant pain and reduce any long-term adverse effects of neonatal intensive care procedures.

许多婴儿在出生时需要新生儿护理，要么是因为早产，要么是因为身体不适。一些最早产和身体不适的婴儿可能会在医院里呆上几个月，在那里他们要接受许多临床手术，其中许多手术会破坏组织，而且可能会很痛苦。尽管努力减少程序和处理的数量，但这些脆弱的个体的负担是相当大的，特别是因为它们发生在大脑发育的关键阶段，当不同大脑区域之间形成连接时。发育中的大脑需要感官刺激才能正常发育，但如果这种刺激被夸大或应用在不适当的发育阶段，它可能会造成永久性伤害。事实上，反复早期暴露于痛苦的程序与大脑的持久不良变化有关。该项目的目的是了解疼痛是如何在人类婴儿大脑中处理的。我们将绘制处理疼痛所必需的大脑回路的结构和功能发展，并研究这些回路如何受到住院期间重复的组织损伤程序的影响。我们将确定这些回路在男性和女性中的发育是否不同。此外，由于疼痛的体验高度依赖于大脑中已经发生的事情以及我们周围发生的事情，我们将探索正在进行的大脑活动如何影响对疼痛刺激的反应，以及我们如何通过非药物干预来操纵这些过程，例如照顾者皮肤对皮肤的护理，以减少所经历的疼痛。这项研究项目将提供我们需要的知识，以减轻婴儿疼痛，减少任何长期的新生儿重症监护程序的不良影响。

项目成果

Sleep-wake regulation in preterm and term infants.

• DOI: 10.1093/sleep/zsaa148
• 发表时间: 2021-01-21
• 期刊: Sleep
• 影响因子: 5.6
• 作者: Georgoulas A;Jones L;Laudiano-Dray MP;Meek J;Fabrizi L;Whitehead K
• 通讯作者: Whitehead K

Encountering Pain Hearing, seeing, speaking

遭遇痛苦 听、看、说

• 发表时间: 2021
• 作者: 池田喬;堀田義太郎;Deborah Padfield & Joanna M. Zakrzewska (eds.) 稲原美苗（12章担当）
• 通讯作者: Deborah Padfield & Joanna M. Zakrzewska (eds.) 稲原美苗（12章担当）

The impact of parental contact upon cortical noxious-related activity in human neonates.

父母接触对人类新生儿皮质有害相关活性的影响。

• DOI: 10.1002/ejp.1656
• 发表时间: 2021-01
• 期刊: European journal of pain (London, England)
• 作者: Jones L;Laudiano-Dray MP;Whitehead K;Meek J;Fitzgerald M;Fabrizi L;Pillai Riddell R
• 通讯作者: Pillai Riddell R

The Oxford Handbook of the Neurobiology of Pain

牛津疼痛神经生物学手册

• 发表时间: 2020
• 作者: Fitzgerald M

Widespread nociceptive maps in the human neonatal somatosensory cortex.

• DOI: 10.7554/elife.71655
• 发表时间: 2022-04-22
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Jones, Laura;Verriotis, Madeleine;Cooper, Robert J.;Laudiano-Dray, Maria Pureza;Rupawala, Mohammed;Meek, Judith;Fabrizi, Lorenzo;Fitzgerald, Maria
• 通讯作者: Fitzgerald, Maria