ADHD AND EXECUTIVE FUNCTIONS--RELATION TO LEARNING DISABILITIES

ADHD 和执行功能——与学习障碍的关系

• 批准号: 6272177
• 负责人: BRUCE F PENNINGTON
• 金额: $ 17.41万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272177
• 关键词: Turner's syndrome; adolescence (12-20); attention deficit disorder; behavioral /social science research tag; clinical research; comorbidity; family genetics; female; fragile X syndromes; genetic disorder diagnosis; human subject; interview; learning disorders; medical complication; middle childhood (6-11); neurofibromatosis; neuropsychological tests; phenylketonurias; psychomotor function; reading disorder; statistics /biometry; twin /multiplet

The overall goal of the proposed research is to use converging methods to better understand the causal relation between RD and its psychiatric correlates particularly ADHD. The specific goals of the proposed research are: 1. To administer measures of attention deficit hyperactivity disorder (ADHD) and executive functions (EFs) to three different populations; a) 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair is reading disabled (RD); b) an independent sample of 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair manifests symptoms of ADHD; and c) a comparison group of 50 pairs of MZ and 50 pairs of DZ twins with no school history of learning disabilities (LDs) or ADHD. 2. To perform a genetic linkage study to identify one or more quantitative trait loci (QTLs) influencing ADHD. 3. To test competing explanations for the association between RD and ADHD using genetic and neuropsychological analyses. 4. To examine the rates and etiology of other psychiatric correlates of RD and ADHD.

拟议研究的总体目标是使用收敛方法 更好地理解RD与其精神疾病之间的因果关系 与多动症尤其相关。 拟议研究的具体目标 是： 1. 实施注意力缺陷多动障碍的治疗措施 （ADHD）和执行功能（EF）针对三个不同的人群； 一个） 50对同卵双胞胎和50对异卵双胞胎，其中至少有一个成员 每对都禁止读取 (RD)； b) 50对独立样本 MZ 和 50 对 DZ 双胞胎，其中每对至少有一个成员 出现多动症症状； c) 50 对 MZ 的对照组 50 对无学习障碍 (LD) 学校历史的 DZ 双胞胎 或多动症。 2. 进行遗传连锁研究以确定一个或多个定量 影响 ADHD 的性状基因座 (QTL)。 3. 测试对 RD 和 ADHD 之间关联的相互竞争的解释 使用遗传和神经心理学分析。 4. 检查 RD 的其他精神相关因素的发生率和病因 和多动症。