ADHD AND EXECUTIVE FUNCTIONS--RELATION TO LEARNING DISABILITIES

ADHD 和执行功能——与学习障碍的关系

• 批准号: 6272177
• 负责人: BRUCE F PENNINGTON
• 金额: $ 17.41万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272177
• 关键词: Turner's syndrome; adolescence (12-20); attention deficit disorder; behavioral /social science research tag; clinical research; comorbidity; family genetics; female; fragile X syndromes; genetic disorder diagnosis; human subject; interview; learning disorders; medical complication; middle childhood (6-11); neurofibromatosis; neuropsychological tests; phenylketonurias; psychomotor function; reading disorder; statistics /biometry; twin /multiplet

The overall goal of the proposed research is to use converging methods to better understand the causal relation between RD and its psychiatric correlates particularly ADHD. The specific goals of the proposed research are: 1. To administer measures of attention deficit hyperactivity disorder (ADHD) and executive functions (EFs) to three different populations; a) 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair is reading disabled (RD); b) an independent sample of 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair manifests symptoms of ADHD; and c) a comparison group of 50 pairs of MZ and 50 pairs of DZ twins with no school history of learning disabilities (LDs) or ADHD. 2. To perform a genetic linkage study to identify one or more quantitative trait loci (QTLs) influencing ADHD. 3. To test competing explanations for the association between RD and ADHD using genetic and neuropsychological analyses. 4. To examine the rates and etiology of other psychiatric correlates of RD and ADHD.

拟议研究的总体目标是使用融合方法来 更好地理解RD与其精神疾病之间的因果关系 尤其与多动症有关。拟议研究的具体目标 包括： 1.实施治疗注意力缺陷多动障碍的措施 (ADHD)和执行功能(EFS)面向三个不同的人群；a) 50对MZ和50对DZ双胞胎，其中至少有一名成员 每对都禁用读取(RD)；b)50对的独立样本 MZ和50对DZ双胞胎，每对至少有一名成员 表现出ADHD症状；以及c)50对MZ和 50对DZ双胞胎，无学习障碍史(LDS) 或者是多动症。 2.进行遗传连锁研究，以确定一个或多个数量 影响ADHD的性状基因座(QTL)。 3.检验对RD和ADHD之间联系的相互矛盾的解释 使用遗传和神经心理学分析。 4.检查RD的其他精神病学相关因素的发生率和病因 和多动症。