VALIDITY OF SUBTYPES OF ADHD

ADHD 亚型的有效性

• 批准号: 6564688
• 负责人: BRUCE F PENNINGTON
• 金额: $ 19.74万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564688
• 关键词: adolescence (12-20); age difference; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; cognition; comorbidity; comprehension; diagnosis design /evaluation; disease /disorder classification; disease /disorder etiology; family genetics; family structure /dynamics; gender difference; human subject; linkage mapping; middle childhood (6-11); neuropsychological tests; questionnaires; reading disorder; statistics /biometry; twin /multiplet

The overall goal of the proposed research is to test the internal and external validity of subtypes of ADHD using converging methods. To accomplish these objectives as part of our ongoing study, we will administer a batter of neuropsychological and psychiatric measures to samples of RD, ADHD, and control twin pairs (50 MZ and 50 DZ pairs in each group) and their siblings. The reliability and internal validity of the ADHD subtypes will be tested by examining inter-rater agreement and test-retest reliability and conducting factor and cluster analyses of individual symptoms. Diagnostic and discriminant validity of the subtypes will be tested by comparing subtypes on measures of functional impairment and other clinical correlates. Etiological relations among the subtypes will be tested using multiple regression analyses of twin data and molecular genetic linkage and association methods, and the cognitive relations among the subtypes will be tested with neuropsychological measures. The neuropsychological battery is designed to test further the executive deficit hypotheses of ADHD by pitting it against competing hypotheses that suggest ADHD is attributable to a deficit in motivation, arousal regulation, or response modulation.

本研究的总体目标是使用收敛方法测试 ADHD 亚型的内部和外部有效性。为了实现这些目标，作为我们正在进行的研究的一部分，我们将对 RD、ADHD 和对照双胞胎样本（每组 50 对 MZ 和 50 对 DZ）及其兄弟姐妹进行一系列神经心理学和精神病学测量。 ADHD 亚型的信度和内部效度将通过检查评估者间的一致性和重测信度以及对个体症状进行因子和聚类分析来测试。将通过比较亚型的功能障碍测量和其他临床相关性来测试亚型的诊断和判别有效性。将使用双胞胎数据的多元回归分析和分子遗传连锁和关联方法来测试亚型之间的病因关系，并使用神经心理学测量来测试亚型之间的认知关系。神经心理学电池旨在进一步测试 ADHD 的执行缺陷假设，将其与表明 ADHD 归因于动机、唤醒调节或反应调节缺陷的竞争假设进行比较。