NEUROPSYCHOLOGY OF DOWN SYNDROME

唐氏综合症的神经心理学

• 批准号: 6108381
• 负责人: BRUCE F PENNINGTON
• 金额: $ 17.74万
• 依托单位: ELEANOR ROOSEVELT INST FOR CANCER RES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6108381
• 关键词: Downs syndrome; adolescence (12-20); behavioral /social science research tag; cerebellum; child (0-11); clinical research; cognition disorders; conditioning; developmental neurobiology; developmental psychology; disease /disorder model; genotype; hippocampus; human subject; laboratory mouse; language development; learning; longitudinal human study; memory; mental retardation; neuroanatomy; neurogenetics; neuromuscular function; neuropsychology; prefrontal lobe /cortex

In contrast to several other mental retardation syndromes, the neuropsychology of Down Syndrome is relatively unexplored. The proposed research will fills gap in existing knowledge by testing the functional status of three neural systems particularly at risk in DS: the prefrontal cortex, hippocampus, and cerebellum. We will examine these three neuropsychological domains in a cross-sectional study of two age cohorts of individuals with DS (n=36 each) compared to two control groups, 1) younger normally developing children matched on MA, and 2) CA and MA matched children with non-DS mental retardation. Our component will provide a target phenotype for our colleagues working with mouse models, which will help them isolate the specific genetic determinants of the neural bases of this form of mental retardation.

与其他几种精神发育迟滞综合征相比， 唐氏综合症的神经心理学是相对未开发的。拟议 研究将通过测试功能来填补现有知识的空白， 三个神经系统的状态，特别是在危险的DS：前额叶 皮质海马和小脑我们将研究这三个 两个年龄组的横断面研究中的神经心理学领域 与两个对照组相比，DS个体（各n=36），1） 正常发育的年轻儿童在MA上匹配，以及2）CA和MA 匹配的非DS智力低下儿童。我们的组件将 为我们研究小鼠模型的同事提供了一个目标表型， 这将帮助他们分离出特定的遗传决定因素， 这种智力迟钝的神经基础。