BRAIN MORPHOMETRY IN READING-DISABLED TWINS

阅读障碍双胞胎的大脑形态分析

• 批准号: 6272180
• 负责人: BRUCE F PENNINGTON
• 金额: $ 17.41万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272180
• 关键词: adolescence (12-20); behavioral /social science research tag; brain imaging /visualization /scanning; cerebral cortex; child mental disorders; clinical research; human subject; magnetic resonance imaging; middle childhood (6-11); neuroanatomy; psycholinguistics; reading disorder; twin /multiplet

The overall goal of the proposed research is to test for genetic and environmental influences on brain structure in reading disability (RD) by performing morphometric analyses of MRI scans collected from RD and non-RD twin pairs. The specific goals of the proposed research are: 1.) To collect MRI scans from 20 twin pairs a year. When combined with the current sample, this will result in a total sample of 80 monozygotic (MZ) and 80 dizygotic (DZ) pairs in which at least one member of each pair will be reading disabled (RD) and 20 DZ pairs in which neither member will be RD. 2.) To perform state-of-the-art morphometric analyses, including cortical parcellation analyses, of these MRI scans targeting structures previously implicated in RD. These morphometric analyses will be performed without knowledge of subjects' diagnosis, relation, or zygosity. 3.) To conduct multivariate behavior genetic analyses of a.) the genetic and environmental components of variation in these morphometric measures and b.) their phenotypic and etiologic relations with behavioral measures. These analyses will be both confirmatory - by testing current strong hypotheses about brain-behavior relations in RD - and exploratory. 4.) To test whether the gene (s) influencing RD also influence brain structures which differentiate individuals with RD from controls. These analyses will use the methods in Research Project 4. 5.) To address basic issues in the new field of in vivo measurement of brain morphometry, such as relations among various brain structures and their relations to external variables, such as sex, age, and cognitive abilities.

拟议研究的总体目标是测试遗传和 环境对阅读障碍（RD）脑结构的影响 对从RD和非RD收集的MRI扫描进行形态测定分析 双胞胎。 拟议研究的具体目标是： 1.）的人。 每年收集20对双胞胎的核磁共振扫描。 当结合 当前样本，这将导致总样本为80个单合子 (MZ)和80个双合子（DZ）对，其中每对中至少有一个成员 将是阅读禁用（RD）和20 DZ对，其中没有成员将 是RD。 2.）的情况。 进行最先进的形态学分析，包括皮质 这些MRI扫描之前针对的结构的分割分析 与RD有关。 这些形态测定分析将在不 受试者的诊断、关系或接合性的知识。 3.）第三章 进行a.）的多变量行为遗传分析。遗传 以及这些形态测量中变化的环境成分 和B.）它们的表型和病因与行为测量的关系。 这些分析都将是验证性的-通过测试电流强 关于RD中脑行为关系的假设-和探索性的。 4.） 为了测试影响RD的基因是否也影响大脑 区分RD个体与对照组的结构。 这些 分析将使用研究项目4中的方法。 5.） 为了解决在体内测量的新领域中的基本问题， 脑形态测量，如各种脑结构之间的关系， 他们与外部变量的关系，如性别，年龄和认知 能力.