NEUROPSYCHOLOGY OF DOWN SYNDROME

与其他几种智力低下综合征不同的是， 唐氏综合症的神经心理学研究相对较少。建议数 研究将通过测试功能来填补现有知识的空白 DS中三个特别危险的神经系统的状况：前额叶 大脑皮层、海马体和小脑。我们将对这三个问题进行研究 两个年龄段队列的横断面研究中的神经心理学领域 患有DS的个体(n=36)与两个对照组相比，1) 年龄较小的正常发育儿童在MA上匹配，以及2)CA和MA 配对的非DS智力低下儿童。我们的组件将 为我们研究老鼠模型的同事提供一个目标表型， 这将帮助他们分离出特定的基因决定因素 这种精神发育迟滞的神经基础。

In contrast to several other mental retardation syndromes, the neuropsychology of Down Syndrome is relatively unexplored. The proposed research will fills gap in existing knowledge by testing the functional status of three neural systems particularly at risk in DS: the prefrontal cortex, hippocampus, and cerebellum. We will examine these three neuropsychological domains in a cross-sectional study of two age cohorts of individuals with DS (n=36 each) compared to two control groups, 1) younger normally developing children matched on MA, and 2) CA and MA matched children with non-DS mental retardation. Our component will provide a target phenotype for our colleagues working with mouse models, which will help them isolate the specific genetic determinants of the neural bases of this form of mental retardation.