FETAL, NEONATAL AND CHILDHOOD EFFECTS OF IN UTERO EXPOSURE TO PCBS AND DDE

宫内接触有机氯化合物的长期影响是 具有巨大的潜在重要性。这些化合物，可以在 基本上，全世界100%的人类都与减少 儿童的神经发育。此外，p，p‘-DDE，主要 DDT的代谢物，是一种弱雌激素和雄激素受体阻滞剂 在人体内观察到的浓度。这个项目的目的是 确定母体血清中DDE浓度是否在 怀孕是隐睾症、尿道下裂和 雄性后代中的多角体。之所以选择这些畸形是因为 它们是子宫内雄激素活性不足的标志。本研究 还将评估子宫内暴露于多氯联苯和 儿童时期的肌肉张力、反应、智商和听力都不太理想。 到目前为止的研究表明，这些化合物可以从 研究人群在相关浓度下，以及相关性 这些化合物在妊娠早期和晚期的浓度之间 血清浓度足够高，可以用晚期妊娠血清作为替代物 用于怀孕初期的暴露。

The long-term effects of in utero exposure to organochlorine compounds is of great potential importance. These compounds, which are detectable in essentially 100% of humans worldwide, have been linked to reduced neurodevelopment in children. In addition, p,p'-DDE, the primary metabolite of DDT, is a weak estrogen, and an androgen receptor blocker at concentrations observed in humans. The purpose of this project is to determine whether maternal serum concentration of DDE, obtained during pregnancy, is a risk factor for cryptorchidism, hypospadias and polythelia in male offspring. These malformations were chosen because they are markers of deficient androgen activity in utero. This study will also evaluate the relationship between in utero exposure to PCBs and suboptimal muscle tone, reflexes, IQ and hearing during childhood. Work to date has demonstrated that these compounds can be recovered from the study population at relevant concentrations, and that the correlation between concentrations of these compounds in first and third trimester serum is sufficiently high to employ third-trimester serum as a surrogate for first-trimester exposure.