Analyses Of Data From The Collaborative Perinatal Projec

围产期合作项目（CPP）是一个丰富的数据集，用于调查与孕产妇和儿童健康有关的各种主题。最近的项目也开始利用从孕妇及其新生儿收集的血清作为本研究的一部分，这与最初研究和随后收集的数据一起沿着提供了独特的资源。2004财政年度调查的领域包括：怀孕所需的时间和怀孕的不良后果、同一妇女相关重复怀孕分析中的统计问题、产妇血清雌激素和雄激素水平和男婴隐睾症、产妇在怀孕期间接触SV-40病毒和儿童癌症、产妇肥胖和双胞胎、随后成年发病精神分裂症的围产期风险因素。在后一项研究中，确定了来自CPP的普罗维登斯和波士顿站点的150多名成年后患精神分裂症的个体，并将其与300多名没有显著精神病病理学的队列成员进行了匹配。在母体和脐带血清中寻找缺氧、病毒感染和免疫激活的证据。2004年开始的分析包括母亲肥胖和双胞胎、母亲吸烟和儿童生长以及儿童癌症的围产期风险因素。

The Collaborative Perinatal Project (CPP) is a rich data set for the investigation of a variety of topics related to maternal and child health. Recent projects have also begun to utilize the serum collected from pregnant women and their neonates as part of this study, which, along with data collected as for the original study and subsequently, provides a unique resource. Areas investigated in FY 04 include, time required to become pregnant and adverse outcomes of the pregnancy, statistical issues in the analysis of correlated repeated pregnancies to the same woman, maternal serum estrogen and androgen levels and cryptorchidism in male infants, maternal exposure to SV-40 virus during pregnancy and childhood cancer, maternal obesity and twinning, perinatal risk factors for subsequent adult-onset schizophrenia. In the latter study, over 150 individuals from the Providence and Boston sites of the CPP who developed schizophrenia as adults were identified and matched to over 300 cohort members who did not have significant psychiatric pathology. Evidence of hypoxia, viral infection, and immune activation was sought in maternal and umbilical cord serum. Analyses begun in 2004 include the maternal obesity and twinning, maternal smoking and childhood growth, and perinatal risk factors for childhood cancer.