LOW BIRTH WEIGHT ACROSS GENERATIONS

在最初描述母亲与婴儿出生体重之间的相关性之后，又描述了大产妇出生体重与分娩巨大儿（>4000克）之间的相关性。对其他胎儿生长参数（包括身长和头围）的研究表明，低出生体重母亲的婴儿比大体重母亲的婴儿更矮更轻，但婴儿的比例正常。在随后的研究中，1979年至1984年出生在田纳西州的婴儿的出生证明与1959年至1966年出生在田纳西州的母亲的出生证明相匹配。产妇和婴儿出生体重再次显示出相关性。此外，出生体重低的妇女生下小于胎龄儿的可能性是出生时体重为4000-4499克的妇女的四倍，但出生体重低的妇女生下早产儿的可能性不到两倍。接下来研究了一组出生于1955年至1965年的瑞典妇女。出生时小于胎龄儿的妇女生小于胎龄儿和早产儿的风险增加。出生时早产的妇女发生这两种结局的风险都没有增加。在丹麦围产期研究（1959-61）中出生的妇女中，发现出生SGA的妇女生SGA孩子的风险增加了一倍，但早产的妇女生早产儿的风险并没有增加。此外，出生时小于胎龄的妇女在怀孕期间患高血压的风险增加。独立的母亲在出生时的大小，父亲在出生时的大小被发现与胎儿的生长，但不与妊娠duration of gestation.Analysis的数据，从出生于20世纪60年代的女孩作为合作围产期项目的主题，目前正在进行中。小胎龄，早产和对照组的女孩已被定位和采访。还检索了她们分娩的医院记录。有关研究方法和成功培训相关因素的数据已经公布。- 体重、胎儿生长、早产、流行病学、群体遗传学-人类受试者和人类受试者：仅访谈、问卷调查或调查

The original description of the correlation between birthweights of mothers and their infants was followed by the description of the association between large maternal birth weight and delivery of a macrosomic (>4000 gram) infant. Study of other fetal growth parameters, including length and head circumference, demonstrated that infants of low birth weight mothers were both shorter and lighter than infants of larger mothers, but that the infants were normally proportioned. In ensuing studies, birth certificates of infants born in Tennessee between 1979 to 1984 were matched with those of their mothers, who were born in Tennessee between 1959 to 1966. Maternal and infant birth weights were again shown to be correlated. In addition, women who were themselves of low birth weight were up to four times as likely to have a small- for-gestational age infant as were women who weighed 4000-4499 grams at birth, but low birth weight women were less than twice as likely to have a preterm infant. A group of Swedish women, born from 1955 to 1965, was next studied. Women who themselves were small-for gestational age at birth were at increased risk of giving birth to both small-for-gestational age and preterm infants. Women who were preterm at birth were not at increased risk of either outcome. Among women born in the Danish Perinatal Study (1959-61), women born SGA were found to be at doubled risk of having an SGA child, but women born preterm were not at increased risk of giving birth to a preterm child. In addition, women who were small-for- gestational age at birth were at increased risk of developing hypertension during pregnancy. Independent of maternal size at birth, paternal size at birth was found to be associated with fetal growth, but not with duration of gestation.Analysis of data from girls who were born in the 1960s as subjects in the Collaborative Perinatal Project is currently underway. Small- for-gestational age, preterm and control girls have been located and interviewed. Hospital records of their deliveries have also been retrieved. Data on study methods and factors associated with successful training have been published. - Birthweight, fetal growth, preterm birth, epidemiology, population genetics - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only