Analyses Of Data From The Collaborative Perinatal Projec

合作围产期项目(CPP)是一个丰富的数据集，用于调查与孕产妇和儿童健康有关的各种主题。最近的项目也开始利用从孕妇及其新生儿收集的血清作为这项研究的一部分，它与最初研究收集的数据一起提供了一个独特的资源。2002财年调查的地区包括婴儿白内障的危险因素、怀孕所需的时间和不良妊娠结局、与同一妇女相关的多次怀孕分析中的统计问题，以及随后成人发作精神分裂症的围产期危险因素。在后一项研究中，来自CPP普罗维登斯和波士顿地点的150多名成年后发展为精神分裂症的人被确认，并与300多名没有明显精神病理的队列成员进行匹配。在母体和脐带血清中寻找缺氧、病毒感染和免疫激活的证据。2002年开始的分析包括孕妇在怀孕期间血清转化为SV-40病毒(1963年之前受污染的索尔克脊髓灰质炎疫苗的结果)是儿童癌症的风险因素，以及孕妇在怀孕期间的类固醇激素水平和男性后代患隐睾症的风险。2003年开始的分析包括宫内暴露于烟草烟雾对月经初潮以后年龄的影响。

The Collaborative Perinatal Project (CPP) is a rich data set for the investigation of a variety of topics related to maternal and child health. Recent projects have also begun to utilize the serum collected from pregnant women and their neonates as part of this study, which, along with data collected as for the original study and subsequently, provides a unique resource. Areas investigated in FY 02 risk factors for infantile cataract, time required to become pregnant and adverse outcomes of the pregnancy, statistical issues in the analysis of correlated repeated pregnancies to the same woman, and perinatal risk factors for subsequent adult-onset schizophrenia. In the latter study, over 150 individuals from the Providence and Boston sites of the CPP who developed schizophrenia as adults were identified and matched to over 300 cohort members who did not have significant psychiatric pathology. Evidence of hypoxia, viral infection, and immune activation was sought in maternal and umbilical cord serum. Analyses begun in 2002 include maternal seroconversion to SV-40 virus during pregnancy (a result of contaminated Salk polio vaccine before 1963) as a risk factor for childhood cancer, as well as maternal steroid hormone levels during pregnancy and the risk of cryptorchidism in male offspring. Analysis to begin in 2003 include the effect of in-utero exposure to tobacco smoke on the subsequent age at menarche