LOW BIRTH WEIGHT ACROSS GENERATIONS

在最初描述母亲出生体重与其婴儿之间的相关性之后，又描述了母亲出生体重大与分娩巨型婴儿（bb0 4000克）之间的关系。对其他胎儿生长参数的研究，包括长度和头围，表明低出生体重母亲的婴儿比大母亲的婴儿更矮更轻，但婴儿的比例正常。在随后的研究中，研究人员将1979年至1984年在田纳西州出生的婴儿的出生证明与其1959年至1966年在田纳西州出生的母亲的出生证明进行了比对。母亲和婴儿的出生体重再次被证明是相关的。此外，出生时体重过轻的女性生出小胎龄婴儿的可能性是出生时体重在4000-4499克的女性的四倍，但出生时体重过轻的女性生出早产婴儿的可能性不到两倍。接下来的研究对象是一组出生于1955年至1965年的瑞典女性。出生时胎龄较小的妇女生下胎龄较小和早产儿的风险更高。早产的妇女没有增加这两种结果的风险。在丹麦围产期研究（1959-61）中出生的妇女中，发现SGA出生的妇女生下SGA孩子的风险增加了一倍，但早产的妇女生下早产儿的风险并没有增加。此外，出生时胎龄较小的妇女在怀孕期间患高血压的风险增加。与母亲出生时的体型无关，父亲出生时的体型与胎儿生长有关，但与妊娠期无关。目前正在对1960年代出生的作为围产期合作项目对象的女孩的数据进行分析。已找到并采访了胎龄小、早产和对照女童。他们分娩的医院记录也被调取。有关成功培训的学习方法和相关因素的数据已经发表。

The original description of the correlation between birthweights of mothers and their infants was followed by the description of the association between large maternal birth weight and delivery of a macrosomic (>4000 gram) infant. Study of other fetal growth parameters, including length and head circumference, demonstrated that infants of low birth weight mothers were both shorter and lighter than infants of larger mothers, but that the infants were normally proportioned. In ensuing studies, birth certificates of infants born in Tennessee between 1979 to 1984 were matched with those of their mothers, who were born in Tennessee between 1959 to 1966. Maternal and infant birth weights were again shown to be correlated. In addition, women who were themselves of low birth weight were up to four times as likely to have a small-for-gestational age infant as were women who weighed 4000-4499 grams at birth, but low birth weight women were less than twice as likely to have a preterm infant. A group of Swedish women, born from 1955 to 1965, was next studied. Women who themselves were small-for gestational age at birth were at increased risk of giving birth to both small-for-gestational age and preterm infants. Women who were preterm at birth were not at increased risk of either outcome. Among women born in the Danish Perinatal Study (1959-61), women born SGA were found to be at doubled risk of having an SGA child, but women born preterm were not at increased risk of giving birth to a preterm child. In addition, women who were small-for-gestational age at birth were at increased risk of developing hypertension during pregnancy. Independent of maternal size at birth, paternal size at birth was found to be associated with fetal growth, but not with duration of gestation. Analysis of data from girls who were born in the 1960's as subjects in the Collaborative Perinatal Project is currently underway. Small-for-gestational age, preterm and control girls have been located and interviewed. Hospital records of their deliveries have also been retrieved. Data on study methods and factors associated with successful training have been published.