DNA MICROHETEROGENEITY & BENDING
DNA微观异质性
基本信息
- 批准号:6279682
- 负责人:
- 金额:$ 6.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-05-01 至 1999-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have previously proposed a structural model for B-DNA with
considerable conformational microheterogeniety in which certain
segments adopt "butter fly" or "rhombic" motifs. To confirm our
proposal, we are determining the structure of three oligomers in
solution by NMR spectroscopy. For the first oligomer, we have
recorded and analyzed the following spectra: 3 'P-'H heteroTOCSY,
homoTOCSY, ECOSY, PECOSY, `P decoupled, H2/H2'' suppressed J scaled
DQF, 'H-"P COSY, 'H_31 P GHSQC, 'H-"C HSQC and NOESY in water and D20
at several mixing times. We have been able to assign all the 'H
resonances. In addition the 20 phosphorus atoms were assigned by a
walk through the hetero 'H_3 'P TOCSY. We have also assigned all the
sugar and backbone carbon atoms in the 13 C HSQC. Thus, we have a
complete description of the sugar phosphate backbone of the 22
individual residues of the AAA duplex.
我们之前提出了一个B-DNA的结构模型
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RAMASWAMY H SARMA其他文献
RAMASWAMY H SARMA的其他文献
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{{ truncateString('RAMASWAMY H SARMA', 18)}}的其他基金
Fourteenth Conversation: Biomolecular Stereodynamics
第十四场对话:生物分子立体动力学
- 批准号:
6989222 - 财政年份:2005
- 资助金额:
$ 6.64万 - 项目类别:
Thirteenth Conversation: Biomolecular Stereodynamics
第十三场对话:生物分子立体动力学
- 批准号:
6672282 - 财政年份:2003
- 资助金额:
$ 6.64万 - 项目类别:
ELEVENTH CONVERSATION--BIOMOLECULAR STEREODYNAMICS
第十一场对话--生物分子立体动力学
- 批准号:
2893522 - 财政年份:1999
- 资助金额:
$ 6.64万 - 项目类别:
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