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15N LABELING OF ANTI HIV I RIBOZYME

15N LABELING OF ANTI HIV I RIBOZYME
抗 HIV I 核酶的 15N 标记
批准号：
6281474
负责人：
RAMASWAMY H SARMA
金额：
$2.0万
依托单位：
UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-01-15 至 1999-01-14
来源：
https://reporter.nih.gov/project-details/6281474
关键词：
AIDS biomedical resource immunology infection inflammation lymphatic system nucleic acids virus

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英文摘要
The SIR provided 13C, "N DNA; 50mg Due to their ability ot specifically recognize targeted sequences through Watson-Crick base pairing, anti-sese NDA/RNA have been shown to be an effective tool in distrpting the life cycle of a virus. Recently it has been shown that the incorporationo f catalytic RNA species derived from small plant pathogenic RNA's further enhanced the therapeutic ability of anti-sense oligonucleotides by overcoming its stoichiometrical requirement. We are studying the abortive complex between a 30-mer ribozyme and a 17-mer DNA analog of HIV- I GAG-RNA. Using uniformly labeled DNA we will employ 3 and 4-D NMR techniques to determine the structure.
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