MODULATION OF BONE RESORPTION BY MECHANICAL STRESSES

描述(改编自调查人员的摘要)：这项拨款建议是 专门授予美国国立卫生研究院“学术研究促进奖”(AREA PA-97-052)。该提案确定了解决重大问题的战略 颅面矫形中的问题，牵涉到什么样的力量 移动的头面部骨骼，以及如何最好地应用它们。申请人 寻求对以方法为主的先导性研究的支持 调查员设计了。本提案的总体目标是 确定具有某些特征的压缩循环力是否尚未 要确定(在这里)，诱导骨吸收比静态更有效 压缩生长兔颅面缝合线的力。工作范围 压缩循环和静力的参数将由以下公式确定 大鼠在体骨应变的大小、模式和速率的量化 这些力量存在于兔子的头面部骨骼中。在长期的负荷下 选定的循环和静力参数，改变骨骼轮廓 矢状面尺寸将通过以标记为导向的头影测量确定 放射摄影术。在活体情况下，颅面缝附近的骨应变将 测定，然后定量的生命染色的新骨形成 通过组织形态计量学分析相同的缝合线。建议进行的研究包括 预期不仅要确定颅面部的反应特征 骨骼到选定的循环和静力参数，而且还关联 颅面缝合线附近的机械应力与缝合量 骨吸收。此外，预期的调查结果将构成以下内容的基础 解决本研究的长期目标是调查 一连串的力参数对大鼠骨吸收的影响 头面部骨骼。

DESCRIPTION (adapted from the Investigator's abstract): This grant proposal is specifically addressed to the NIH "Academic Research Enhancement Award" (AREA PA-97-052). This proposal has identified strategies to address a significant problem in craniofacial orthopedics, what sorts of forces are involved in moving craniofacial bones, and how best they should be applied. The applicant seeks support for pilot research studies with methods the Principal Investigator has designed. The overall goal of the present proposal is to determine whether compressive cyclic forces with certain characteristics, yet to be determined (here), induce bone resorption more effectively than static forces that compress craniofacial sutures in growing rabbits. A working range of parameters of compressive cyclic and static forces will be determined by quantifying the magnitude, mode and rate of in vivo bone strain induced by these forces in rabbit craniofacial bones. Following chronic loading with selected cyclic and static force parameters, alteration of bone contour in the sagittal dimension will be determined by marker-orientated cephalometric radiography. In vivo bone strain adjacent to craniofacial sutures will be determined, followed by quantification of vital-stained new bone formation in the same sutures by histomorphometric analyses. The proposed studies are anticipated not only to determine the response characteristics of craniofacial bones to selected parameters of cyclic and static forces, but also to correlate mechanical stresses adjacent to craniofacial sutures with the amount of sutural bone resorption. In addition, the anticipated findings will form the basis of addressing the long-term goal of the present research to investigate the effects of a cascade of force parameters on inducing bone resorption in craniofacial bones.