HIGH-SPEED MRI FOR TUMOR INTERVENTIONS

描述（改编自申请人的摘要）：本申请是一个 竞争性更新最初的项目涉及新的快速磁共振 影像学（MRI）技术用于改善腹部肿瘤的诊断。 在开发几种快速扫描方法方面取得了重大进展， 在屏气时产生高质量的T2加权腹部图像。重点 这种竞争性的更新是新的MR方法， 肿瘤检测-指导肿瘤活检和其他介入治疗 项目标题已修改，以反映这一变化 聚焦。本项目的目标是：1）设计和实现一个实时的， 交互式（RTI）MRI系统，为介入手术量身定制，2）开发 并将提供有用图像的新序列集成到RTI系统中 用于介入手术的对比剂;以及3）评价这种新的MR 介入系统对体模和患者影响。研究计划包括 多功能RTI MRI平台的实质性技术开发， 改进的MR采集方法（例如，稳态自由旋进，快速自旋 回波和彩色血流），并进行系统测试，以验证 结果系统一个拥有广泛技术和临床经验的研究团队 为这个项目汇集了专门知识。这种专业知识，沿着 最先进的扫描仪，使斯坦福大学成为理想的 环境，来实施这个项目。

DESCRIPTION (Adapted from Applicant's Abstract): This application is a competing renewal. The original project concerned new fast magnetic resonance imaging (MRI) techniques for improved diagnosis of abdominal tumors. Significant progress was made in developing several fast-scan methods that produce high-quality T2-weighted abdominal images in a breath-hold. The focus of this competing renewal is on new MR methods that take the next step beyond tumor detection---the guidance of tumor biopsies and other interventional procedures using MR. The project title has been modified to reflect this change in focus. The aims of this project are to 1) design and implement a real-time, interactive (RTI) MRI system tailored for interventional procedures, 2) develop and integrate into the RTI system new sequences that provide useful image contrast for interventional procedures; and 3) evaluate this new MR interventional system on phantoms and patients. The research plan includes substantial technical development of a versatile RTI MRI platform, studies of improved MR acquisition methods (e.g., steady-state free precession, fast spin echo, and color flow), and systematic tests to validate the performance of the resultant system. A research team with extensive technical and clinical expertise has been assembled for this project. This expertise, along with the state-of-the-art scanners available, make Stanford University an ideal environment to carry out this project.