OPTIMIZED MEASUREMENT AND SIGNAL PROCESSING OF FETAL MCG

描述(改编自申请人摘要)：本申请请求 继续支持研究人员在胎儿发育过程中的工作 心磁图(FMCG)作为一种新的无创检测技术 来自子宫内人类胎儿的功能信息。快消品是唯一 可以高精度评估胎儿心率和节律的技术，以及 因此可能会对围产期科学和临床产生重大影响 练习一下。调查人员之前的发现表明， FMCG对胎儿节律紊乱的诊断价值尤其高。他们有 演示了几个胎儿节律紊乱的例子，可能是 被快速消费品检测到，但不能被超声波检测到。重要的是，他们还能够 推断潜在的机制。快速消费品也是一种近乎理想的信号源 胎儿心率监测，提供精确的信号，不受产妇影响 干扰，可以在怀孕的后半部分检测到。这个 研究人员已经证明，它可以提供重要的诊断信息， 无法通过其他手段获得，这些手段有可能提高准确性 对胎儿进行监测。研究的长期目标是将快速消费品发展成 一种可提高胎儿心脏功能临床评估水平的方法 胎儿健康。该项目的主要技术目标是：1.制造 使用新获得的快速消费品记录大范围的胎龄 最先进的仪器，并评估质量和成功率 2.应用专门的信号处理技术 可以显著提高FMCG记录的信噪比 从而提高较小波形分量的分辨率，这些较小的波形分量 对胎儿节律的评估是必不可少的。在这些进步的基础上， 主要的科学目标是：3.对患有糖尿病的患者进行连续测量 广泛的胎心节律异常，以显示疗效 FMCG在重度胎儿发病机制及发育研究中的应用 心律失常，并记录FMCG可以提供 与超声相比具有重要的诊断优势；以及4.在 比以前可能的更早的孕周，并使用这些记录 评估胎儿心率变异性，胎儿心脏波形参数，以及 正常和高危胎儿健康的其他潜在指标 怀孕。

DESCRIPTION (Adapted from Applicant's Abstract): This application requests support to continue the investigators work in developing fetal magnetocardiography (FMCG) as a new noninvasive technology for obtaining functional information from the human fetus in utero. FMCG is the only technique that can assess fetal heart rate and rhythm with high precision, and thus could have a significant impact on perinatal science and clinical practice. The investigators previous finding to date suggest that the potential of FMCG is especially high for evaluation of fetal rhythm disorders. They have demonstrated several examples of fetal rhythm disturbances that could be detected by FMCG, but not by ultrasound. Importantly they were also able to infer the underlying mechanisms. FMCG is also a nearly ideal signal source for fetal hear rate monitoring, providing a precise signal, free of maternal interference, which can be detected throughout the last half of pregnancy. The investigators have shown that it can provide important diagnostic information, unobtainable by other means, which have the potential to improve the accuracy of fetal monitoring. The long-term goal of the research is to develop FMCG into a method that can improve clinical assessment of fetal cardiac function and fetal well being. The primary technical aims of the project are: 1. To make FMCG recordings over a wide range of gestational ages using newly acquired state-of-the-art instrumentation, and to evaluate the quality and success rate of the measurements; and 2. To apply specialized signal processing technology which can significantly increase the signal-to-noise ratio of FMCG recordings and thereby improve the resolution of smaller waveform components, which are essential for assessment of fetal rhythm. Building upon these advances, the primary scientific aims are: 3. To perform serial measurements in patients with a wide range of fetal rhythm abnormalities in order to demonstrate the efficacy of FMCG for investigating the mechanisms and development of serious fetal arrhythmia, and to document specific cases in which FMCG can provide an important diagnostic advantage over ultrasound; and 4. To record the FMCG at earlier gestational ages than previously possible, and to use these recording to assess fetal heart rate variability, fetal cardiac waveform parameters, and other potential indicators of fetal well-being in normal and high risk pregnancies.