OPTIMIZED MEASUREMENT AND SIGNAL PROCESSING OF FETAL MCG

描述（改编自申请人的摘要）：本申请要求 支持继续研究人员在胎儿发育方面的工作 心磁图（FMCG）作为一种新的无创技术，用于获取 来自子宫内人类胎儿的功能信息。快消品是唯一 可以高精度评估胎儿心率和节律的技术，以及 因此可能对围产期科学和临床产生重大影响 练习。研究人员迄今为止的先前发现表明，潜在的 快速消费品对于胎儿节律紊乱的评估尤其重要。他们有 展示了几个胎儿节律紊乱的例子 通过快速消费品可以检测到，但不能通过超声波检测到。重要的是他们还能够 推断潜在的机制。快消品也是近乎理想的信号源 胎儿心率监测，提供精准信号，不受母体影响 干扰，可以在整个怀孕的后半段检测到。的 研究人员表明它可以提供重要的诊断信息， 通过其他方式无法获得，这有可能提高准确性 胎儿监测。研究的长期目标是将快速消费品发展为 一种可以改善胎儿心功能临床评估的方法 胎儿健康。该项目的主要技术目标是： 1. 使用新获取的各种胎龄的快速消费品记录 最先进的仪器，并评估质量和成功率 测量结果； 2.应用专门的信号处理技术 可显着提高快消品录音的信噪比 从而提高较小波形分量的分辨率，这些分量是 对于评估胎儿节律至关重要。在这些进步的基础上， 主要科学目标是： 3. 对患有以下疾病的患者进行系列测量 广泛的胎儿节律异常以证明功效 快速消费品研究严重胎儿畸形的机制和发育 心律失常，并记录快速消费品可以提供的具体案例 与超声相比具有重要的诊断优势； 4. 将快速消费品记录在 孕龄比以前可能的更早，并使用这些记录 评估胎儿心率变异性、胎儿心脏波形参数，以及 正常和高风险胎儿健康的其他潜在指标 怀孕。

DESCRIPTION (Adapted from Applicant's Abstract): This application requests support to continue the investigators work in developing fetal magnetocardiography (FMCG) as a new noninvasive technology for obtaining functional information from the human fetus in utero. FMCG is the only technique that can assess fetal heart rate and rhythm with high precision, and thus could have a significant impact on perinatal science and clinical practice. The investigators previous finding to date suggest that the potential of FMCG is especially high for evaluation of fetal rhythm disorders. They have demonstrated several examples of fetal rhythm disturbances that could be detected by FMCG, but not by ultrasound. Importantly they were also able to infer the underlying mechanisms. FMCG is also a nearly ideal signal source for fetal hear rate monitoring, providing a precise signal, free of maternal interference, which can be detected throughout the last half of pregnancy. The investigators have shown that it can provide important diagnostic information, unobtainable by other means, which have the potential to improve the accuracy of fetal monitoring. The long-term goal of the research is to develop FMCG into a method that can improve clinical assessment of fetal cardiac function and fetal well being. The primary technical aims of the project are: 1. To make FMCG recordings over a wide range of gestational ages using newly acquired state-of-the-art instrumentation, and to evaluate the quality and success rate of the measurements; and 2. To apply specialized signal processing technology which can significantly increase the signal-to-noise ratio of FMCG recordings and thereby improve the resolution of smaller waveform components, which are essential for assessment of fetal rhythm. Building upon these advances, the primary scientific aims are: 3. To perform serial measurements in patients with a wide range of fetal rhythm abnormalities in order to demonstrate the efficacy of FMCG for investigating the mechanisms and development of serious fetal arrhythmia, and to document specific cases in which FMCG can provide an important diagnostic advantage over ultrasound; and 4. To record the FMCG at earlier gestational ages than previously possible, and to use these recording to assess fetal heart rate variability, fetal cardiac waveform parameters, and other potential indicators of fetal well-being in normal and high risk pregnancies.