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Optimized Measurement and Signal Processing of Fetal MCG

胎儿 MCG 的优化测量和信号处理

基本信息

批准号：
9975872
负责人：
RONALD T WAKAI
金额：
$ 47.49万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9975872
关键词：
Adoption Adult American Heart Association American Medical Association Area Arrhythmia Birth Blood Circulation Cardiac Electrophysiologic Techniques Cardiology Categories Clinical Clinical Management Collaborations Current Procedural Terminology Codes Development Devices Diagnosis Diagnostic Disease Disease Progression Echocardiography Electrocardiogram Electrophysiology (science)Evaluation Fetal Development Fetal Heart Rate Fetus Frequencies Generations Goals High-Risk Pregnancy Human Infrastructure Investigation Life Light Long QT Syndrome Magnetism Measurement Methods Optics Positioning Attribute Pregnancy Pump Research Research Personnel Role Symptoms System Techniques Technology Testing Unexplained fetal death Work analog clinical application cost effective defined contribution effective therapy experience fetal fetal diagnosis fetus at risk high risk improved new technology programs signal processing

项目摘要

ABSTRACT Noninvasive assessment of fetal cardiac electrophysiology has not been routinely possible despite many decades of fetal ECG research. Recently, however, we and other groups have demonstrated the utility of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as an effective new method of assessing fetal heart rate, rhythm, and conduction. The long-term goal of this program is to develop fMCG as a new technology for fetal investigation and clinical application. If successful, the research can improve the diagnosis of life-threatening forms of fetal arrhythmia and shed light on causes of unexplained fetal death. The last few years have seen remarkable progress in demonstrating the diagnostic efficacy of fMCG. Crucial progress has also been made toward the development of fMCG technology. During the next project period, we will focus on several areas that are critical to overcoming the obstacles to clinical adoption of fMCG. FMCG is still a very new area. Additional human studies are needed to better define and further expand the role of fMCG for clinical management of fetal long QT syndrome and other life-threatening fetal arrhythmia. Optically-pumped magnetometers (OPMs) represent an important breakthrough that can overcome a major barrier to clinical adoption of fMCG by making the technique more practical and cost-effective. The specific aims are as follows: 1. Perform serial studies of fetuses at risk of LQTS. Little is known about the development of LQTS prior to birth. The studies are needed to ascertain how early symptoms manifest, follow the progression of the disease, and help determine the frequency and timing of fMCG sessions for optimal clinical management of fetal LQTS. 2. Continue our studies of pregnancies complicated by fetal arrhythmia and other high-risk pregnancy conditions. The proposed studies will help define the contribution of fMCG for clinical management of a range of serious fetal arrhythmia, including some that have not been previously studied. 3. Demonstrate the efficacy of OPMs as a new technology for fMCG. We will directly compare recordings made with an OPM system and an FDA-cleared SQUID magnetometer.

摘要对胎儿心脏电生理的非侵入性评估并不是常规的可能，尽管几十年的胎儿心电研究。然而，最近，我们和其他小组已经展示了这种实用程序胎儿心磁图(FMCG)是胎儿心电的磁性模拟物，是一种有效的新方法评估胎儿心率、节律和传导。该计划的长期目标是开发快速消费品作为一种新的胎儿调查和研究技术临床应用。如果成功，这项研究可以提高对危及生命的胎儿形式的诊断心律失常，并阐明不明原因的胎儿死亡原因。在过去的几年里，在展示快速消费品的诊断效能方面取得了显著的进展。快速消费品技术的发展也取得了关键进展。在下一个项目中在此期间，我们将重点关注几个领域，这些领域对于克服快速消费品临床采用的障碍至关重要。快速消费品仍然是一个非常新的领域。需要更多的人体研究来更好地定义和进一步扩展 FMCG在胎儿长QT间期综合征及其他危及生命的胎儿心律失常的临床处理中的作用光泵磁力计(OPM)是一项重大突破，可以克服重大的通过使该技术更实用和更具成本效益，阻碍了快速消费品的临床应用。具体的目标如下： 1.对有LQTS风险的胎儿进行系列研究。关于LQTS的发展，人们知之甚少在出生之前。这些研究需要确定早期症状是如何表现出来的，遵循疾病的进展，并帮助确定快速消费品疗程的频率和时间胎儿LQTS的最佳临床处理。 2.继续研究妊娠合并胎儿心律失常和其他高危妊娠条件。拟议的研究将有助于确定快速消费品对临床管理的贡献一系列严重的胎儿心律失常，包括一些以前没有研究过的。 3.论证了OPMS作为一种快速消费品新技术的有效性。我们将直接比较使用OPM系统和FDA批准的SQUID磁强计进行记录。

项目成果

期刊论文数量（45）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

HTS magnetometers for fetal magnetocardiography.

用于胎儿心磁图的 HTS 磁力计。

DOI：
发表时间：
2004
期刊：
Neurology & clinical neurophysiology : NCN
影响因子：
0
作者：
Li,Z;Wakai,RT;Paulson,DN;Schwartz,B
通讯作者：
Schwartz,B

Fetal QT Interval Estimation Using Sequential Hypothesis Testing.

使用序贯假设检验估计胎儿 QT 间期。

DOI：
10.1109/tbme.2017.2661248
发表时间：
2017
期刊：
IEEE transactions on bio-medical engineering
影响因子：
0
作者：
Yu,Suhong;VanVeen,BarryD;Lutter,WilliamJ;Wakai,RonaldT
通讯作者：
Wakai,RonaldT

Magnetophysiologic and echocardiographic comparison of blocked atrial bigeminy and 2:1 atrioventricular block in the fetus.

DOI：
10.1016/j.hrthm.2013.04.020
发表时间：
2013-08
期刊：
HEART RHYTHM
影响因子：
5.5
作者：
Wiggins, Delonia L.;Strasburger, Janette F.;Gotteiner, Nina L.;Cuneo, Bettina;Wakai, Ronald T.
通讯作者：
Wakai, Ronald T.

Magnetocardiography in the evaluation of fetuses at risk for sudden cardiac death before birth.

心磁图评估胎儿出生前心源性猝死的风险。