Optimized Measurement and Signal Processing of Fetal MCG

胎儿 MCG 的优化测量和信号处理

• 批准号: 7090706
• 负责人: RONALD T WAKAI
• 金额: $ 34.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7090706
• 关键词: arrhythmia; bioimaging /biomedical imaging; biomagnetism measurement; body movement; cardiography; clinical biomedical equipment; congenital heart disorder; diagnosis design /evaluation; disease /disorder proneness /risk; embryo /fetus; embryo /fetus monitoring; gestational age; heart rate; heart rhythm; human pregnant subject; patient oriented research; pregnancy disorder; technology /technique development; ultrasonography

DESCRIPTION (provided by applicant): The long-term goal of the research is to develop fMCG into a technique that can improve clinical assessment of fetal arrhythmia and fetal well-being. The last few years have seen substantial progress toward this goal, as promising results continue to be reported by our group and by others. In several cases of serious fetal arrhythmia, we have already shown that fMCG can improve outcome. However, the total number of cases studied worldwide is small and further technical development in needed. The goal of the present application is to extend the capability of fMCG to make it more similar to postnatal electrophysiological monitoring, and to demonstrate the usefulness of these extensions by applying them in patient studies. The specific aims are as follows. 1. To reduce the ambiguity of fMCG configuration by using knowledge of probe position and orientation to characterize waveform morphology as a function of fetal presentation 2. To improve the sensitivity of fMCG actography, a new method of assessing fetal activity, by combining information from multiple channels 3. To improve fMCG signal quality by developing adaptive filtering methods to compensate for fetal and maternal movement 4. To apply the methods developed in Aims 1-3 to more fully characterize the patterns of fetal heart rhythm, fetal heart rate, and fetal activity in cases of fetal arrhythmia, congenital heart disease, and high-risk pregnancies.

描述（由申请人提供）： 该研究的长期目标是将 fMCG 开发成一种可以改善胎儿心律失常和胎儿健康的临床评估的技术。过去几年，我们的团队和其他人不断报告有希望的结果，在实现这一目标方面取得了实质性进展。在几起严重胎儿心律失常的病例中，我们已经证明 fMCG 可以改善预后。然而，全世界研究的案例总数很少，需要进一步的技术开发。本申请的目标是扩展 fMCG 的功能，使其更类似于产后电生理监测，并通过将其应用于患者研究来证明这些扩展的有用性。具体目标如下。 1. 通过使用探头位置和方向的知识来表征作为胎儿先露的函数的波形形态，以减少 fMCG 配置的模糊性 2. 通过组合来自多个通道的信息，提高 fMCG 体动描记法（一种评估胎儿活动的新方法）的灵敏度 3. 通过开发自适应滤波方法来补偿胎儿和母亲的运动，以提高 fMCG 信号质量 4. 应用 Aims 中开发的方法 1-3 更全面地描述胎儿心律失常、先天性心脏病和高危妊娠情况下的胎儿心律、胎儿心率和胎儿活动的模式。