Neurodevelopmental MEG

神经发育脑磁图

• 批准号: 7841924
• 负责人: RONALD T WAKAI
• 金额: $ 18.17万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7841924
• 关键词: Age; Auditory Evoked Potentials; Birth; Brain; Cerebral Palsy; Childhood; Chronic; Data Analyses; Development; Diagnosis; Evaluation; Functional disorder; Goals; Head Movements; Infant; Longitudinal Studies; Magnetoencephalography; Mental Retardation; Methods; Neonatal; Neuraxis; Neurodevelopmental Disorder; Perinatal; Research; Resolution; Sleep; Source; System; Techniques; Technology; Wakefulness; base; design; expectation; improved; neurodevelopment; new technology; outcome forecast; postnatal; programs; public health relevance

DESCRIPTION (provided by applicant): The long-term goal of this research program is to demonstrate the efficacy of magnetoencephalography (MEG) as a new technology for the study of neonatal brain activity. There is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults, which may result in mental retardation and neurodevelopmental disorders. We believe that MEG will prove to be an important technology for evaluation of neurodevelopment, including abnormal neurodevelopment. This expectation is based on its ability to provide high spatial as well as temporal resolution of brain activity, it's extremely high sensitivity to developmental changes, and the paucity of alternative methods of assessing neurodevelopment. We propose a longitudinal study to follow the development of brain activity and its underlying sources from birth through age 18 months. The study is designed to further explore recent findings which demonstrate the utility of MEG for characterization of neonatal brain activity, including its potential to provide improved correlates of neurodevelopment. An important technical goal of the research is to develop methods to compensate for head movement, which has been a major limitation in pediatric MEG studies. The goals of the research are: 1. To implement a head movement tracking system for neonatal MEG and to evaluate methods of incorporating head movement information into MEG data analysis. 2. To carry out longitudinal studies of brain rhythms and auditory evoked responses in normal full-term infants healthy during sleep and wakefulness. PUBLIC HEALTH RELEVANCE: The long-term goal of this research program is to demonstrate the efficacy of magnetoencephalography (MEG) as a new technology for the study of perinatal brain activity. Currently there is a paucity of effective, noninvasive techniques for assessment of neurodevelopment. Such a technology could be invaluable for diagnosis and prognosis of babies with brain dysfunction due to chronic intrauterine central nervous system insults, which may result in cerebral palsy and neurodevelopmental disorders.

描述（由申请人提供）：本研究项目的长期目标是证明脑磁图（MEG）作为研究新生儿大脑活动的新技术的有效性。长期以来，人们一直需要一种技术，可以帮助诊断和预后由于宫内和产后中枢神经系统损伤导致的脑功能障碍婴儿，这可能导致智力迟钝和神经发育障碍。我们相信MEG将成为评估神经发育，包括异常神经发育的重要技术。这种期望是基于它提供大脑活动的高空间和时间分辨率的能力，它对发育变化的高度敏感性，以及评估神经发育的替代方法的缺乏。我们建议进行一项纵向研究，以跟踪大脑活动的发展及其潜在来源，从出生到18个月。该研究旨在进一步探索最近的发现，这些发现证明了MEG在新生儿大脑活动表征方面的效用，包括其提供改善神经发育相关因素的潜力。该研究的一个重要技术目标是开发补偿头部运动的方法，这一直是儿童MEG研究的主要限制。本研究的目标是：1。实施新生儿脑磁图头部运动跟踪系统，并评估将头部运动信息纳入脑磁图数据分析的方法。2. 对正常足月婴儿在睡眠和清醒状态下的脑节律和听觉诱发反应进行纵向研究。公共卫生相关性：本研究项目的长期目标是证明脑磁图（MEG）作为围产期脑活动研究的新技术的有效性。目前缺乏有效的、无创的神经发育评估技术。这种技术对于慢性宫内中枢神经系统损伤可能导致脑瘫和神经发育障碍的脑功能障碍婴儿的诊断和预后具有不可估量的价值。

项目成果

Slow rhythms and sleep spindles in early infancy.

• DOI: 10.1016/j.neulet.2016.07.051
• 发表时间: 2016-09-06
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Wakai RT;Lutter WJ
• 通讯作者: Lutter WJ