Optimized Measurement and Signal Processing of Fetal MCG

描述(由申请人提供)： 这项研究的长期目标是将FMCG发展成为一种可以改善胎儿心律失常和胎儿健康的临床评估技术。在过去的几年里，随着我们的小组和其他人继续报告有希望的结果，朝着这一目标取得了实质性的进展。在几个严重的胎儿心律失常病例中，我们已经证明FMCG可以改善预后。然而，全世界研究的病例总数很少，需要进一步的技术开发。本申请的目的是扩展FMCG的能力，使其更类似于出生后电生理监测，并通过将其应用于患者研究来证明这些扩展的有用性。具体目标如下。1.通过利用探头位置和方向的知识来表征波形形态作为胎儿呈现的函数来减少FMCG配置的模糊性2.通过结合来自多个通道的信息来提高FMCG活动评估的新方法的灵敏度3.通过开发自适应滤波方法来补偿胎儿和母体的运动来改善FMCG信号质量4.应用目标1-3中开发的方法来更全面地表征胎儿心律失常、先天性心脏病和高危妊娠的胎儿心率、胎儿活动的模式

DESCRIPTION (provided by applicant): The long-term goal of the research is to develop fMCG into a technique that can improve clinical assessment of fetal arrhythmia and fetal well-being. The last few years have seen substantial progress toward this goal, as promising results continue to be reported by our group and by others. In several cases of serious fetal arrhythmia, we have already shown that fMCG can improve outcome. However, the total number of cases studied worldwide is small and further technical development in needed. The goal of the present application is to extend the capability of fMCG to make it more similar to postnatal electrophysiological monitoring, and to demonstrate the usefulness of these extensions by applying them in patient studies. The specific aims are as follows. 1. To reduce the ambiguity of fMCG configuration by using knowledge of probe position and orientation to characterize waveform morphology as a function of fetal presentation 2. To improve the sensitivity of fMCG actography, a new method of assessing fetal activity, by combining information from multiple channels 3. To improve fMCG signal quality by developing adaptive filtering methods to compensate for fetal and maternal movement 4. To apply the methods developed in Aims 1-3 to more fully characterize the patterns of fetal heart rhythm, fetal heart rate, and fetal activity in cases of fetal arrhythmia, congenital heart disease, and high-risk pregnancies.