Optimized Measurement and Signal Processing of Fetal MCG

胎儿 MCG 的优化测量和信号处理

• 批准号: 8857219
• 负责人: RONALD T WAKAI
• 金额: $ 41.61万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8857219
• 关键词: Adult; Arrhythmia; Cardiac Electrophysiologic Techniques; Clinical; Data; Detection; Development; Diagnosis; Diagnostic; Echocardiography; Electrocardiogram; Evaluation; Fetal Heart Rate; Fetal Monitoring; Fetal Therapies; Fetus; Future; Gestational Age; Goals; Health; Investigation; Knowledge; Life; Light; Long QT Syndrome; Magnetism; Measurement; Measures; Mechanics; Methodology; Methods; Modality; Monitor; Outcome; Patients; Personal Satisfaction; Physiologic pulse; Positioning Attribute; Predictive Value; Pregnancy; Publishing; Research; Research Personnel; Study Subject; Techniques; Technology; Time; Ultrasonography; Unexplained fetal death; Work; analog; base; clinical application; congenital heart disorder; detector; experience; fetal; fetus at risk; heart rate variability; heart rhythm; high risk; improved; innovation; interest; new technology; postnatal; prenatal therapy; programs; signal processing; theories

DESCRIPTION (provided by applicant): Noninvasive assessment of fetal cardiac electrophysiology has not been routinely possible despite many decades of fetal ECG research. Recently, however, we and other groups have demonstrated the efficacy of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as an effective new method of assessing fetal heart rate, rhythm, and conduction. The long-term goal of this program is to develop fMCG as a new technology for fetal investigation and clinical application. If successful, this research can improve the diagnosis of life-threatening forms of fetal arrhythmia and shed light on causes of unexplained fetal death. It can also provide an effective means of monitoring the effects of fetal therapies and can aid in the evaluation of new therapies. The short-term objective of the research proposed here is to extend the functionality of fMCG by combining it with other techniques and to perform further patient studies to increase the base of scientific knowledge in the nascent field of fetal cardiac electrophysiology. The specific aims are as follows: 1. Develop and apply detectors based on statistical estimation and detection theory to identify repolarization abnormalities, such as QTc prolongation and T-wave alternans. 2. Develop and apply methodology for analysis of simultaneous fMCG/echocardiography recordings in order to directly compare fetal electrical and mechanical rhythm and evaluate fetal electromechanical function. 3. Combine fetal actocardiography with ultrasound surveillance in order to improve the assessment of fetal well-being. 4. Continue our studies of normal pregnancies and pregnancies complicated by fetal arrhythmia and other high-risk conditions, incorporating techniques developed in the preceding aims.

描述（由申请人提供）：尽管胎儿心电图研究已有数十年，但对胎儿心脏电生理学的无创评估尚未成为常规可能。然而，最近，我们和其他小组已经证明了胎儿心磁图（fMCG）（胎儿心电图的磁模拟）作为评估胎儿心率、节律和传导的有效新方法的功效。该项目的长期目标是将fMCG开发为胎儿研究和临床应用的新技术。如果成功，这项研究可以改善对危及生命的胎儿心律失常的诊断，并揭示不明原因胎儿死亡的原因。它还可以提供监测胎儿疗法效果的有效手段，并有助于评估新疗法。这里提出的研究的短期目标是通过将 fMCG 与其他技术相结合来扩展 fMCG 的功能，并进行进一步的患者研究，以增加胎儿心脏电生理学新兴领域的科学知识基础。具体目标如下： 1.开发和应用基于统计估计和检测理论的检测器来识别复极异常，例如QTc延长和T波交替。 2. 开发并应用同时分析 fMCG/超声心动图记录的方法，以便直接比较胎儿电和机械节律并评估胎儿机电功能。 3. 将胎儿心电图与超声监测相结合，以改进对胎儿健康状况的评估。 4. 结合上述目标中开发的技术，继续对正常妊娠和并发胎儿心律失常和其他高风险状况的妊娠进行研究。