OPTIMIZED MEASUREMENT AND SIGNAL PROCESSING OF FETAL MCG

胎儿 MCG 的优化测量和信号处理

• 批准号: 6437226
• 负责人: RONALD T WAKAI
• 金额: $ 1.89万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6437226
• 关键词: arrhythmia; biomagnetism measurement; cardiography; clinical biomedical equipment; clinical research; diagnosis design /evaluation; embryo /fetus; embryo /fetus monitoring; gestational age; heart rate; heart rhythm; human subject; technology /technique development

DESCRIPTION (Adapted from Applicant's Abstract): This application requests support to continue the investigators work in developing fetal magnetocardiography (FMCG) as a new noninvasive technology for obtaining functional information from the human fetus in utero. FMCG is the only technique that can assess fetal heart rate and rhythm with high precision, and thus could have a significant impact on perinatal science and clinical practice. The investigators previous finding to date suggest that the potential of FMCG is especially high for evaluation of fetal rhythm disorders. They have demonstrated several examples of fetal rhythm disturbances that could be detected by FMCG, but not by ultrasound. Importantly they were also able to infer the underlying mechanisms. FMCG is also a nearly ideal signal source for fetal hear rate monitoring, providing a precise signal, free of maternal interference, which can be detected throughout the last half of pregnancy. The investigators have shown that it can provide important diagnostic information, unobtainable by other means, which have the potential to improve the accuracy of fetal monitoring. The long-term goal of the research is to develop FMCG into a method that can improve clinical assessment of fetal cardiac function and fetal well being. The primary technical aims of the project are: 1. To make FMCG recordings over a wide range of gestational ages using newly acquired state-of-the-art instrumentation, and to evaluate the quality and success rate of the measurements; and 2. To apply specialized signal processing technology which can significantly increase the signal-to-noise ratio of FMCG recordings and thereby improve the resolution of smaller waveform components, which are essential for assessment of fetal rhythm. Building upon these advances, the primary scientific aims are: 3. To perform serial measurements in patients with a wide range of fetal rhythm abnormalities in order to demonstrate the efficacy of FMCG for investigating the mechanisms and development of serious fetal arrhythmia, and to document specific cases in which FMCG can provide an important diagnostic advantage over ultrasound; and 4. To record the FMCG at earlier gestational ages than previously possible, and to use these recording to assess fetal heart rate variability, fetal cardiac waveform parameters, and other potential indicators of fetal well-being in normal and high risk pregnancies.

描述（改编自申请人摘要）：本申请要求 支持研究人员继续开展胎儿发育方面的工作 心磁图（FMCG）作为一种新的非侵入性技术， 子宫内人类胎儿的功能信息FMCG是唯一 能够以高精度评估胎儿心率和节律的技术，以及 因此可能对围产期科学和临床产生重大影响 实践研究人员先前的发现表明， FMCG的检测对于胎儿节律紊乱的评估尤其高。他们有 证明了几个胎儿节律紊乱的例子， 通过快速消费品检测，而不是通过超声波。重要的是，他们还能够 推断潜在的机制。快速消费品也是一个近乎理想的信号源， 胎儿心率监测，提供精确的信号，不受母体 干扰，这可以在怀孕的后半期检测到。的 研究人员已经表明，它可以提供重要的诊断信息， 无法通过其他手段获得，这有可能提高精度 胎儿监护研究的长期目标是将快速消费品发展成为 一种可以改善胎儿心脏功能临床评估的方法， 胎儿健康该项目的主要技术目标是：1。使 使用新获得的数据在广泛的胎龄范围内进行快速消费品记录 最先进的仪器，并评估质量和成功率 测量结果;以及2.应用专门的信号处理技术 这可以显著增加FMCG记录的信噪比 从而提高较小波形分量的分辨率， 对评估胎儿节律至关重要。在这些进步的基础上， 主要的科学目的是：3。在患有以下疾病的患者中进行系列测量 广泛的胎儿节律异常，以证明疗效 快速消费品的研究机制和发展严重的胎儿 心律失常，并记录具体情况下，快速消费品可以提供一个 超声波的重要诊断优势;和4.记录快速消费品在 更早的孕龄比以前可能的，并使用这些记录 评估胎儿心率变异性、胎儿心脏波形参数，以及 正常和高风险胎儿健康的其他潜在指标 怀孕。