Elucidating the potential interaction of manufactured nanoparticles with polycyclic aromatic hydrocarbons: an integrated toxicogenomics approach

阐明人造纳米粒子与多环芳烃的潜在相互作用:综合毒物基因组学方法

基本信息

  • 批准号:
    NE/L006138/1
  • 负责人:
  • 金额:
    $ 23.29万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2014
  • 资助国家:
    英国
  • 起止时间:
    2014 至 无数据
  • 项目状态:
    已结题

项目摘要

Particles in the range of 1-100 nanometers (a nanometer is one billionth of a meter) are termed nanoparticles and are widely present in the environment. But, man-made nanoparticles (i.e. engineered nanoparticles or ENPs) are of tremendous technological and economic interest. They have a wide range of potential applications in environmental remediation, medical and consumer products. The small sizes of ENPs give them special chemical properties, making them potentially reactive. These particles are being discharged, voluntary or involuntary, into the environment in common with other pollutants such as those present in diesel exhaust, oil leaks and spills, tobacco smokes. These chemicals are collectively known as polycyclic aromatic hydrocarbons (PAHs) and they have known detrimental effects on the health of humans and the natural biota, including induction of cancer. The reactive property of ENPs can potentially cause harm to humans and other life forms and in the environment, they can occur in all probable combinations with other pollutants such as PAHs. They can interact and behave in different ways, opposed to when they are present on their own in the environment. Their potential interactive effects are however unknown. Within the cells (the smallest unit of life), they can cause damage to biomolecules (e.g. membranes, proteins and DNA). In addition to direct interaction of ENPs and PAHs with biomolecules (e.g. DNA, cell membrane), the resultant damage could be through the formation of highly reactive molecules called free radicals which are involved in many pathological conditions, which we aim to measure using specific technique, the methodologies for which have not been properly developed. This is particularly so in cases where they are brought into contact with water under different conditions (e.g. salinity, acidity, oxygen level etc.) either alone or in combinations with other pollutants such as PAHs. We will be synthesise ENPs in our laboratory and will characterise them for their specific properties in various conditions, track their uptake by the mussels (alone or in combination with PAHs) and localise them in different tissues using analytical techniques where appropriate. Using two chemically different, widely used, environmentally relevant ENPs (i.e. C60 fullerenes and carbon nanotubes), the aim of the present proposal is to determine the potential effects of these ENPs either alone or in combinations with environmentally relevant PAHs. We will be using a range of biological measures, which will include damage to DNA or genes, the blueprint of life, and determine how either the single or group of genes behave in different conditions, which could lead to potential detrimental effects in different organs or tissues of marine mussels. We will vary the extent of damage produced, by altering the exposure conditions (chronically or acute) and will also determine the antioxidants levels to correlate the effects. The damaging effect of generated radicals on cell membranes will also be examined. We will use modelling techniques to incorporate individual biological responses to draw a bigger picture of potential effects. Using analytical techniques, we will determine the levels of ENPs and PAHs in seawater and the tissues of the organism and will correlate these levels with observed effects. Such an approach will help us to determine the potential risk to our health from these chemicals and will inform the regulators and the industries to take appropriate actions to safeguard the health of humans and the environment. We will use the generated information to explain the pathways of exposure to ENPs and PAHs and suggest ways to reduce any potential harm. This may also have application in the treatment of diseases such as cancer. We will share the information with the scientific community, industries, and all other stake holders.
在1-100纳米范围内的颗粒(一纳米是十亿分之一米)被称为纳米颗粒,广泛存在于环境中。但是,人造纳米颗粒(即工程纳米颗粒或ENPs)具有巨大的技术和经济利益。它们在环境修复、医疗和消费品方面具有广泛的潜在应用。ENPs的小尺寸赋予它们特殊的化学性质,使它们具有潜在的反应性。这些颗粒被排放到环境中,自愿或非自愿,与其他污染物,如柴油废气,漏油和溢出,烟草烟雾中存在的污染物一样。这些化学品统称为多环芳烃(PAH),已知它们对人类健康和自然生物群具有有害影响,包括诱发癌症。ENPs的反应特性可能会对人类和其他生命形式造成危害,并且在环境中,它们可以与其他污染物(如多环芳烃)的所有可能组合出现。它们可以以不同的方式进行互动和行为,而不是单独存在于环境中。然而,其潜在的相互影响尚不清楚。在细胞(生命的最小单位)内,它们可以对生物分子(例如膜,蛋白质和DNA)造成损害。除了ENPs和PAH与生物分子(例如DNA,细胞膜)的直接相互作用外,所产生的损害可能是通过形成称为自由基的高反应性分子,这些分子参与许多病理条件,我们的目标是使用特定的技术来测量,其方法尚未得到适当的开发。在不同条件(例如盐度、酸度、氧气水平等)下与水接触的情况下尤其如此。单独或与其他污染物如多环芳烃结合。我们将在我们的实验室合成ENPs,并将在各种条件下对其特定特性进行表征,跟踪贻贝对其的吸收(单独或与多环芳烃结合),并在适当的情况下使用分析技术将其定位在不同的组织中。使用两种化学上不同的,广泛使用的,环境相关的ENPs(即C60富勒烯和碳纳米管),本提案的目的是确定这些ENPs单独或与环境相关的多环芳烃组合的潜在影响。我们将使用一系列生物学措施,其中包括对DNA或基因的损伤、生命蓝图,并确定单个或一组基因在不同条件下的表现,这可能会导致不同器官或组织的潜在有害影响。海洋贻贝。我们将通过改变暴露条件(慢性或急性)来改变所产生的损害程度,并确定抗氧化剂水平以关联影响。还将检查所产生的自由基对细胞膜的破坏作用。我们将使用建模技术,将个人的生物反应,以绘制一个更大的图片的潜在影响。使用分析技术,我们将确定海水和生物组织中ENPs和PAH的水平,并将这些水平与观察到的影响相关联。这种方法将有助于我们确定这些化学品对我们健康的潜在风险,并将告知监管机构和行业采取适当行动,以保护人类和环境的健康。我们将使用生成的信息来解释暴露于ENPs和PAH的途径,并提出减少任何潜在危害的方法。这也可以应用于治疗疾病如癌症。我们将与科学界、工业界和所有其他利益相关者分享信息。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Growth of single-layer boron nitride dome-shaped nanostructures catalysed by iron clusters.
铁簇催化单层氮化硼圆顶形纳米结构的生长。
  • DOI:
    10.1039/c6nr03474h
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    6.7
  • 作者:
    Torre AL
  • 通讯作者:
    Torre AL
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Andrei Khlobystov其他文献

Andrei Khlobystov的其他文献

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{{ truncateString('Andrei Khlobystov', 18)}}的其他基金

Metal Atoms on Surfaces & Interfaces (MASI) for Sustainable Future
表面上的金属原子
  • 批准号:
    EP/V000055/1
  • 财政年份:
    2021
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Research Grant
High resolution, cryogenic analytical and transfer scanning electron microscope (HR-CAT-SEM)
高分辨率、低温分析和转移扫描电子显微镜 (HR-CAT-SEM)
  • 批准号:
    EP/S021434/1
  • 财政年份:
    2019
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Research Grant
NanoPrime: Maximising Equipment and Expertise Sharing in Nanoscience
NanoPrime:最大限度地共享纳米科学的设备和专业知识
  • 批准号:
    EP/R025282/1
  • 财政年份:
    2018
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Research Grant
Triggering, Controlling and Imaging Chemical Reactions at the Single-Molecule Level by Electron Beam
通过电子束触发、控制和成像单分子水平的化学反应
  • 批准号:
    EP/R024790/1
  • 财政年份:
    2018
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Fellowship
Multi-Functional Nanoscale Platforms: Bridging the Gap between Molecular and Macroscopic Worlds
多功能纳米平台:弥合分子世界和宏观世界之间的差距
  • 批准号:
    EP/L014696/1
  • 财政年份:
    2013
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Research Grant
Non-Covalent Assembly of Functional Nanostructures
功能纳米结构的非共价组装
  • 批准号:
    EP/C545273/1
  • 财政年份:
    2006
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Fellowship
IDEAS Factory - Chemical Craftwork: Directed Assembly of Functional Patterns (Brianchell)
IDEAS Factory - 化学工艺:功能图案的定向组装 (Brianchell)
  • 批准号:
    EP/D023777/1
  • 财政年份:
    2006
  • 资助金额:
    $ 23.29万
  • 项目类别:
    Research Grant

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  • 批准号:
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  • 批准年份:
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  • 批准号:
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    2007
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    28.0 万元
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