PRENATAL ALCOHOL USE EFFECT ON PEDIATRIC OUTCOME

一个由650名女性组成的队列， 在第四次和第七次采访中， 怀孕几个月。 这些妇女和她们的后代被评估为 分娩，8个月和18个月，3年和6年。 下一阶段 纵向研究将评估生长，认知发展， 形态异常、行为运动技能和神经心理学 孩子们9岁时的表现。 我们预计， 产前酒精暴露的影响将在年龄较大时检测到， 对孩子们提出了更复杂的要求，要求他们掌握越来越多的 认知任务和运动技能的困难程度。 第二部分的建议，将重点放在发展的方法 预防或减少怀孕期间饮酒。 我们将评估 将预防协议与具体 妇女的特征，使用社会人口统计学定义的概况， 心理因素和药物使用模式。

A cohort of 650 women who represented the entire spectrum of drinking practice during pregnancy was interviewed in the fourth and seventh months of pregnancy. These women and their offspring were assessed at delivery, at 8 and 18 months and 3 and 6 years. The next phase of this longitudinal study will assess growth, cognitive development, morphological anomalies, behavior motor skills, and neuropsychological performance of the children at age 9. We anticipate that additional effects of prenatal alcohol exposure will be detected at an older age as more complex demands are made on the children for mastery of increasingly difficult levels of cognitive tasks and motor skills. The second part of the proposal, will focus on the development of methods to prevent or reduce drinking during pregnancy. We will evaluate the effectiveness of matching prevention protocols to specific characteristics of the women, using profiles defined by sociodemographic and psychological factors and substance use patterns of the women.