PRENATAL ALCOHOL EXPOSURE: LONG-TERM OUTCOMES

描述(由申请人提供)：这是一份针对计划公告进行二次数据分析的建议：PA-01-140。产妇保健做法和儿童发展项目为评估产前接触酒精的儿童的成长和发育提供了一个独特的机会。该项目中的妇女在她们出生前的第四个月和第七个月接受了采访。妇女和她们的后代在孩子出生时、8个月和18个月、3、6、10、14和16岁时进行评估。这个队列是从一家产前诊所挑选出来的，一半是白人，一半是非洲裔美国人。这一队列中的女性代表了怀孕期间饮酒的整个范围。在每个阶段，我们测量人口状况、心理、社会和家庭环境、母亲和父亲的物质使用情况，以及家庭中男性伴侣的物质使用情况。我们评估了孩子们的认知、行为、学业和身体状况。在10岁、14岁和16岁时，我们对青春期成熟度、神经心理状态、认知和行为发展、情感、学习成绩、精神状态、犯罪行为、药物使用和朋友的药物使用情况进行了额外的测量。这项为期16年的评估没有为酒精数据的分析提供资金。 在拟议的分析中，我们将确定16岁产前酒精暴露的影响。此外，我们将把这项评估与之前的阶段结合起来，并评估这些儿童在研究的多个时间点的生长发育情况。在16岁时，我们将评估酒精和其他物质使用障碍、精神障碍、犯罪、行为以及社会和学术问题的发展。我们将评估产前酒精暴露对这些结果的影响。目前关于青少年药物使用和滥用的开始或过程的研究都没有纳入产前酒精暴露的影响的确定，胎儿酒精文献也没有考虑物质使用的开始和过程。这项提案将整合这些研究领域。

DESCRIPTION (provided by applicant): This is a proposal for a secondary data analysis in response to a Program Announcement: PA-01-140. The Maternal Health Practices and Child Development Project provides a unique opportunity to assess the growth and development of children who were prenatally exposed to alcohol. The women in this project were interviewed during their fourth and seventh prenatal months. Women and their offspring were assessed at the child's birth, 8 and 18 months, 3, 6, 10, 14, and 16 years of age. The cohort was selected from a prenatal clinic and is half Caucasian and half African-American. The women in this cohort represent the entire spectrum of alcohol use during pregnancy. At each phase, we measured demographic status, the psychological, social, and household environment, maternal and paternal substance use, and the substance use of the male partner in the household. We assessed the children's cognitive, behavioral, academic, and physical status. At ages 10, 14, and 16, we have additional measures of pubertal maturity, neuropsychological status, cognitive and behavioral development, affect, academic performance, psychiatric status, delinquent behaviors, substance use, and the substance use of their friends. The 16-year assessment was not funded for the analysis of the alcohol data. In the proposed analyses, we will identify the effects of prenatal alcohol exposure at age 16. In addition, we will integrate this assessment with the prior phases, and assess the growth and development of these children across the multiple time points of the study. At 16 years, we will evaluate the development of alcohol and other substance use disorders, psychiatric disorders, delinquency, behavior, and social and academic problems. We will assess the effects of prenatal alcohol exposure on these outcomes. None of the current research on the onset or course of adolescent substance use and abuse has incorporated the identification of the effects of prenatal alcohol exposure, nor has the fetal alcohol literature considered the onset and course of substance use. This proposal will integrate these areas of research.