Dissecting the function and therapeutic potential of Hedgehog signaling in breast cancer

剖析 Hedgehog 信号在乳腺癌中的功能和治疗潜力

• 批准号: nhmrc : 1051348
• 负责人: A/Pr Alexander Swarbrick
• 金额: $ 30.62万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-function-therapeutic-breast-cancer/112211
• 关键词: Dissecting; function; therapeutic; potential; Hedgehog

Breast cancer cells create the conditions for their own survival by communicating their needs with to the healthy cells that surround them. We have previously shown that a molecule known as ‘hedgehog’ transmits biochemical signals between the cancer cells and healthy cells. When hedgehog is ‘silenced’, tumours shrink and stop their spread. In this application, we explore the fundamental biology of Hedgehog signaling and its potential as a drug target for breast cancer.

乳腺癌细胞通过与周围的健康细胞交流他们的需求来为自己的生存创造条件。我们之前已经证明，一种被称为“刺猬”的分子在癌细胞和健康细胞之间传递生化信号。当刺猬被“沉默”时，肿瘤会缩小并阻止其扩散。在本申请中，我们探索了Hedgehog信号传导的基础生物学及其作为乳腺癌药物靶点的潜力。